Measurement properties of the Patient-Reported Outcomes Measurement Information System Itch Questionnaire item banks in adults with atopic dermatitis

• Published in: Journal of the American Academy of Dermatology Vol. 82; no. 5; pp. 1174 - 1180
• Main Authors: Silverberg, Jonathan I., Lai, Jin-Shei, Vakharia, Paras P., Patel, Kevin, Singam, Vivek, Chopra, Rishi, Sacotte, Ryan, Patel, Neha, Rastogi, Supriya, Kantor, Robert, Hsu, Derek Y., Cella, David
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2020
• Subjects: atopic dermatitis; burden; eczema; itch; patient-reported outcomes; pruritus; quality of life; severity; severity; pruritus; DIF; DLQI; itch; patient-reported outcomes; SCORAD; POEM; AD; atopic dermatitis; PRO; NRS; oSCORAD; burden; QOL; SD; EASI; SF; VRS; eczema; PIQ; quality of life; ClinRO; 5D-Itch
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/j.jaad.2019.11.057

The Patient-Reported Outcomes Measurement Information System (PROMIS) Itch Questionnaire (PIQ) was recently developed. To validate PIQ short forms in adults with AD. Self-administered questionnaires and skin examinations were performed in 239 adults with atopic dermatitis (AD) in a dermatology practice setting. PIQ items had good content validity. PIQ item bank T-scores strongly correlated with each other, moderately correlated with numeric and verbal rating scales for worst or average itch and with itch frequency, moderately to strongly correlated with patient-oriented eczema measure, and weakly to moderately correlated with the Eczema Area and Severity Index and Objective-Scoring AD (Spearman correlations, P < .0001). There were significant and stepwise increases of T-scores for all item banks with increasing patient-reported global severity (Wilcoxon rank sum test, P < .0001). However, there was limited ability to discriminate between the lowest or highest 2 levels of AD or itch severity. Item banks showed good internal consistency (Cronbach α, 0.91-0.95). No differential item functioning was identified by age, sex, race/ethnicity, or educational level. There were floor effects for total scores, particularly in almost clear/mild AD or itch. Single-center study. PIQ item bank short forms showed good content and construct validity and are feasible for potential use in clinical trials and practice.