Heat-sensitive moxibustion attenuates the inflammation after focal cerebral ischemia/ reperfusion injury

Heat-sensitive moxibustion has neuroprotective effects against focal cerebral ischemia/reperfusion injury, however its mechanism of action remains unclear. In this study, rat models of focal cerebral ischemia/reperfusion injury were treated with suspended moxibustion at acupoint Dazhui （DU14） for 35...

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Published inNeural regeneration research Vol. 7; no. 33; pp. 2600 - 2606
Main Authors Xiao, Aijiao, Chen, Rixin, Kang, Mingfei, Tan, Shenghai
Format Journal Article
LanguageEnglish
Published India Medknow Publications & Media Pvt. Ltd 25.11.2012
Basal Medical College of Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,Jiangxi Province,China%Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,Jiangxi Province,China%Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,Jiangxi Province,China
Medknow Publications & Media Pvt Ltd
Subjects
Acupuncture and Moxibustion and Neural Regeneration
Cytokines
Inflammation
Ischemia
Neutrophils
Surgery
再灌注损伤
大鼠模型
感热
炎症
神经保护作用
细胞因子
缺血
脑
过氧化物酶活性
cerebral ischemia/reperfusion injury
proinflammatory cytokines
heat-sensitive moxibustion
neural regeneration
traditional Chinese medicine
myeloperoxidase
traditional suspended moxibustion
interleukin
infarct volume
suspended moxibustion
middle cerebral artery occlusion
traditional Chinese medi
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Summary:Heat-sensitive moxibustion has neuroprotective effects against focal cerebral ischemia/reperfusion injury, however its mechanism of action remains unclear. In this study, rat models of focal cerebral ischemia/reperfusion injury were treated with suspended moxibustion at acupoint Dazhui （DU14） for 35 minutes. Results showed that suspended moxibustion decreased infarct volume, reduced cortical myeloperoxidase activity, and suppressed serum levels of proinflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury. Our experimental findings indicated that heat-sensitive moxibustion can attenuate inflammation and promote repair after focal cerebral ischemia/reperfusion injury.
Bibliography:suspended moxibustion; heat-sensitive moxibustion; traditional suspended moxibustion; middlecerebral artery occlusion; cerebral ischemia/reperfusion injury; infarct volume; proinflammatorycytokines; interleukin; myeloperoxidase; traditional Chinese medicine; neural regeneration
Aijiao Xiao, Rixin Chen, Mingfei Kang, Shenghai Tan（ 1 Basal Medical College of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China 2 Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, Jiangxi Province, China 3 Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China ）
Heat-sensitive moxibustion has neuroprotective effects against focal cerebral ischemia/reperfusion injury, however its mechanism of action remains unclear. In this study, rat models of focal cerebral ischemia/reperfusion injury were treated with suspended moxibustion at acupoint Dazhui （DU14） for 35 minutes. Results showed that suspended moxibustion decreased infarct volume, reduced cortical myeloperoxidase activity, and suppressed serum levels of proinflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury. Our experimental findings indicated that heat-sensitive moxibustion can attenuate inflammation and promote repair after focal cerebral ischemia/reperfusion injury.
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Author contributions: Aijiao Xiao participated in the experimental operation, data collection, statistical analysis, and writing the paper. Rixin Chen supervised the project and provided critical comments on the manuscript. Mingfei Kang provided study guidance and coordinated the study. Shenghai Tan performed the neurological assessment and moxibustion treatment. All authors read and approved the final manuscript.
Aijiao Xiao, M.D., Associate professor, Basal Medical College of Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi Province, China
Author statements: The manuscript is original, has not been submitted to or is not under consideration by another publication, has not been previously published in any language or any form, including electronic, and contains no disclosure of confidential information or authorship/ patent application disputations.
ISSN:1673-5374
1876-7958
DOI:10.3969/j.issn.1673-5374.2012.33.005