Stimulatory and Protective Effects of Alkylating Agents Applied in Ultra-Low Concentrations

Alkylating drugs belonging to the nitrogen mustard family are known as cytostatic and immunosuppressive agents. Ultra-low doses of these drugs may demonstrate pharmacological effects unlike this category of drugs. In the case of a gradual dose decrease, the number of targets for alkylation is also r...

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Bibliographic Details
Published inPharmacology Vol. 62; no. 3; pp. 129 - 132
Main Authors Pukhalsky, Alexander L., Shmarina, Galina V.
Format Journal Article
LanguageEnglish
Published Basel, Switzerland S. Karger AG 01.01.2001
Subjects
Alkylating Agents - administration & dosage
Alkylating Agents - metabolism
Alkylating Agents - pharmacology
Alkylating Agents - therapeutic use
Epithelial Cells - drug effects
Epithelial Cells - physiology
Fas Ligand Protein
fas Receptor - metabolism
Humans
Inflammation - drug therapy
Lymphocytes - drug effects
Membrane Glycoproteins - metabolism
Perspective Note
Receptors, Interleukin-2 - metabolism
Fas ligand
Epithelial cells
Alkylating agents
IL-2 receptor
Fas
Inflammation
Apoptosis
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Summary:Alkylating drugs belonging to the nitrogen mustard family are known as cytostatic and immunosuppressive agents. Ultra-low doses of these drugs may demonstrate pharmacological effects unlike this category of drugs. In the case of a gradual dose decrease, the number of targets for alkylation is also reduced and the drug switches from cytostatic to cell growth modifier. We postulate that application of ultra-low doses of alkylating drugs may result in a beneficial effect in the therapy of diseases associated with chronic inflammation of the mucosa, especially with the signs of epithelial atrophy.
ISSN:0031-7012
1423-0313
DOI:10.1159/000056084