p73 and IGF1R Regulate Emergence of Aggressive Cancer Stem-like Features via miR-885-5p Control

• Published in: Cancer research (Chicago, Ill.) Vol. 76; no. 2; pp. 197 - 205
• Main Authors: Meier, Claudia, Hardtstock, Philip, Joost, Sophie, Alla, Vijay, Pützer, Brigitte M
• Format: Journal Article
• Language: English
• Published: United States 15.01.2016
• Subjects: Animals; Cell Line, Tumor; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; HEK293 Cells; Heterografts; Humans; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Melanoma - genetics; Melanoma - metabolism; Melanoma - pathology; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs - genetics; MicroRNAs - metabolism; Neoplastic Stem Cells - pathology; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Receptors, Somatomedin - metabolism; Transfection; Tumor Protein p73; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism

Cancer stem-like cells (CSC) have been proposed to promote cancer progression by initiating tumor growth at distant sites, suggesting that stem-like cell features can support metastatic efficiency. Here, we demonstrate that oncogenic DNp73, a dominant-negative variant of the tumor-suppressor p73, co...