Discriminative stimulus properties of clozapine and chlorpromazine

Rats were trained to discriminate pairs of drug states in a two-lever operant paradigm for food reinforcement. One group learned to discriminate clozapine from vehicle, a second group learned to discriminate chlorpromazine from vehicle, and a third group learned to discriminate clozapine from chlorp...

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Published inPharmacology, biochemistry and behavior Vol. 8; no. 3; pp. 235 - 241
Main Authors Allen Goas, J., Boston, James E.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.1978
Subjects
Animals
Chlorpromazine
Chlorpromazine - pharmacology
Clozapine
Clozapine - pharmacology
Dibenzazepines - pharmacology
Discrimination (Psychology) - drug effects
Discriminative stimulus
Drug discrimination
Electroshock
Haloperidol - pharmacology
Male
Rats
Discriminative stimulus
Drug discrimination
Clozapine
Chlorpromazine
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Summary:Rats were trained to discriminate pairs of drug states in a two-lever operant paradigm for food reinforcement. One group learned to discriminate clozapine from vehicle, a second group learned to discriminate chlorpromazine from vehicle, and a third group learned to discriminate clozapine from chlorpromazine. The result that the clozapine versus chlorpromazine discrimination was acquired, as well as the results of substitution tests with non-training drugs, suggest that the stimulus properties of the classical neuroleptic chlorpromazine are different from those of clozapine. Substitution tests with clozapine, classical neuroleptics and other psychotherapeutic agents indicate that the stimulus properties of antipsychotics are distinct from other classes of psychotropic agents, and support the hypothesis that clozapine may be a unique antipsychotic. It is suggested that the unique discriminative stimulus produced by clozapine may be related to the differential effect of the drug on the extrapyramidal versus accumbens dopamine system.
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ISSN:0091-3057
1873-5177
DOI:10.1016/0091-3057(78)90310-6