In situ forming parenteral depot systems based on poly(ethylene carbonate): Effect of polymer molecular weight on model protein release

• Published in: European journal of pharmaceutics and biopharmaceutics Vol. 85; no. 3; pp. 1245 - 1249
• Main Authors: Chu, Dafeng, Curdy, Catherine, Riebesehl, Bernd, Beck-Broichsitter, Moritz, Kissel, Thomas
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2013
• Subjects: Animals; Biocompatible Materials - chemistry; Cattle; Chemistry, Pharmaceutical - methods; Diffusion; Drug Delivery Systems; Drug release; Drug Stability; Hydrogen-Ion Concentration; In situ forming depots; Infusions, Parenteral; Initial burst; Microscopy, Electron, Scanning; Molecular Weight; Particle Size; Poly(ethylene carbonate); Polyethylenes - chemistry; Polymers - chemistry; Serum Albumin, Bovine - chemistry; Solvents - chemistry; Surface-eroding polymers; Viscosity; Water - chemistry; Water swelling; Drug release; Water swelling; Poly(ethylene carbonate); Surface-eroding polymers; Initial burst; In situ forming depots
• ISSN: 0939-6411; 1873-3441; 1873-3441
• DOI: 10.1016/j.ejpb.2013.05.020

[Display omitted] The objective of this study was to investigate the effect of molecular weight (MW) on the drug release from poly(ethylene carbonate) (PEC) based surface-eroding in situ forming depots (ISFD). In phosphate buffered saline (PBS) pH 7.4, 63.7% of bovine serum albumin BSA was released from high MW PEC of 200kDa (PEC200) in DMSO (15%, w/w) in 2days, while during the same time period, the release of BSA from PEC41 samples was only 22.5%. At higher concentrations of PEC41 (25%, w/w), the initial burst was further reduced, and even after 6days, only 16.3% was released. Compared to depots based on PEC200, there was lower rate of solvent release, slower phase inversion, and a denser surface in PEC41 samples. An expansion in size of PEC41 depots suggested that the polymer barrier of PEC41 impeded the diffusion of solvent out of the samples effectively. In conclusion, the initial burst of protein from ISFD of PEC41 was significantly reduced, which would be a promising candidate as polymeric carrier.