Human-specific insertion/deletion polymorphisms in Indian populations and their possible evolutionary implications

DNA samples from 396 unrelated individuals belonging to 14 ethnic populations of India, inhabiting various geographical locations and occupying various positions in the socio-cultural hierarchy, were analysed in respect of 8 human-specific polymorphic insertion/deletion loci. All loci, except Alu CD...

Full description

Saved in:
Bibliographic Details
Published inEuropean journal of human genetics : EJHG Vol. 7; no. 4; pp. 435 - 446
Main Authors Majumder, P P, Roy, B, Banerjee, S, Chakraborty, M, Dey, B, Mukherjee, N, Roy, M, Thakurta, P G, Sil, S K
Format Journal Article
LanguageEnglish
Published England 01.05.1999
Subjects
Alleles
Alu Elements - genetics
Biological Evolution
CD4 Antigens - genetics
DNA, Mitochondrial - analysis
Ethnic Groups - genetics
Gene Deletion
Gene Frequency
Genetics, Population
Humans
India
Polymorphism, Genetic
Online AccessGet full text

Cover

More Information
Summary:DNA samples from 396 unrelated individuals belonging to 14 ethnic populations of India, inhabiting various geographical locations and occupying various positions in the socio-cultural hierarchy, were analysed in respect of 8 human-specific polymorphic insertion/deletion loci. All loci, except Alu CD4, were found to be highly polymorphic in all populations. The levels of average heterozygosities were found to be very high in all populations and, in most populations, also higher than those predicted by the island model of population structure. The coefficient of gene differentiation among Indian populations was found to be higher than populations in most other global regions, except Africa. These results are discussed in the light of two possible scenarios of evolution of Indian populations in the broader context of human evolution.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1018-4813
1476-5438
DOI:10.1038/sj.ejhg.5200317