Tooth shape formation and tooth renewal: evolving with the same signals

Teeth are found in almost all vertebrates, and they therefore provide a general paradigm for the study of epithelial organ development and evolution. Here, we review the developmental mechanisms underlying changes in tooth complexity and tooth renewal during evolution, focusing on recent studies of...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 139; no. 19; pp. 3487 - 3497
Main Authors Jernvall, Jukka, Thesleff, Irma
Format Journal Article
LanguageEnglish
Published England 01.10.2012
Subjects
Animals
Biological Evolution
Humans
Models, Biological
Odontogenesis - genetics
Odontogenesis - physiology
Organ Size - genetics
Organogenesis - genetics
Organogenesis - physiology
Regeneration - genetics
Regeneration - physiology
Signal Transduction - genetics
Signal Transduction - physiology
Tooth - embryology
Tooth - growth & development
Tooth - metabolism
Tooth - physiology
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Summary:Teeth are found in almost all vertebrates, and they therefore provide a general paradigm for the study of epithelial organ development and evolution. Here, we review the developmental mechanisms underlying changes in tooth complexity and tooth renewal during evolution, focusing on recent studies of fish, reptiles and mammals. Mammals differ from other living vertebrates in that they have the most complex teeth with restricted capacity for tooth renewal. As we discuss, however, limited tooth replacement in mammals has been compensated for in some taxa by the evolution of continuously growing teeth, the development of which appears to reuse the regulatory pathways of tooth replacement.
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ISSN:0950-1991
1477-9129
DOI:10.1242/dev.085084