Manganese oxide-modified bismuth oxychloride piezoelectric nanoplatform with multiple enzyme-like activities for cancer sonodynamic therapy

• Published in: Journal of colloid and interface science Vol. 640; pp. 839 - 850
• Main Authors: Zhao, Yunchao, Huang, Tian, Wang, Shaobo, Yao, Shuncheng, Hu, Quanhong, Wan, Xingyi, Guo, Ning, Zhang, Yang, Li, Linlin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.06.2023
• Subjects: Animals; Bismuth oxychloride; Cell Line, Tumor; Enzyme-like activity; Humans; Hydrogen Peroxide; Manganese oxide; Mice; Neoplasms - therapy; Oxygen - metabolism; Piezotronic effect; Reactive Oxygen Species - metabolism; Sonodynamic therapy; Enzyme-like activity; Piezotronic effect; Bismuth oxychloride; Sonodynamic therapy; Manganese oxide
• ISSN: 0021-9797; 1095-7103
• DOI: 10.1016/j.jcis.2023.03.008

[Display omitted] Sonodynamic therapy (SDT) is considered as a new-rising strategy for cancer therapeutics, but the inefficient production of reactive oxygen species (ROS) by current sonosensitizers seriously hinders its further applications. Herein, a piezoelectric nanoplatform is fabricated for enhancing SDT against cancer, in which manganese oxide (MnOx) with multiple enzyme-like activities is loaded on the surface of piezoelectric bismuth oxychloride nanosheets (BiOCl NSs) to form a heterojunction. When exposed to ultrasound (US) irradiation, piezotronic effect can remarkably promote the separation and transport of US-induced free charges, and further enhance ROS generation in SDT. Meanwhile, the nanoplatform shows multiple enzyme-like activities from MnOx, which can not only downregulate the intracellular glutathione (GSH) level, but also disintegrate endogenous hydrogen peroxide (H2O2) to generate oxygen (O2) and hydroxyl radicals (•OH). As a result, the anticancer nanoplatform substantially boosts ROS generation and reverses tumor hypoxia. Ultimately, it reveals remarkable biocompatibility and tumor suppression in a murine model of 4 T1 breast cancer under US irradiation. This work provides a feasible pathway for improving SDT using piezoelectric platforms.