Pentraxin-3 in coronary artery disease: A meta-analysis
•Prognostic values of blood pentraxin-3 level in CAD patients have yielded conflicting results.•CAD patients with the highest pentraxin-3 level had an 81% higher risk of all-cause mortality.•CAD patients with the highest pentraxin-3 level had a 77% higher risk of cardiac death.•ACS patients with the...
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Published in | Cytokine (Philadelphia, Pa.) Vol. 119; pp. 197 - 201 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.07.2019
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Subjects | |
Online Access | Get full text |
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Summary: | •Prognostic values of blood pentraxin-3 level in CAD patients have yielded conflicting results.•CAD patients with the highest pentraxin-3 level had an 81% higher risk of all-cause mortality.•CAD patients with the highest pentraxin-3 level had a 77% higher risk of cardiac death.•ACS patients with the highest pentraxin-3 level had a 62% higher risk of cardiac events.•Determination of pentraxin-3 level has potential to improve risk stratification of CAD patients.
Studies on the prognostic significance of circulating pentraxin-3 level in patients with coronary artery disease (CAD) have yielded conflicting results. The aim of this meta-analysis was to evaluate the prognostic value of circulating pentraxin-3 level in CAD patients.
We made a systematic literature search in Pubmed, Embae, CNKI, Wanfang, and VIP database from their inception to January 10, 2019 for prospective cohort studies that investigated the association between pentraxin-3 level and adverse outcomes in patients with CAD. The outcome measures were all-cause mortality, cardiac death, and cardiac events (cardiac death, nonfatal myocardial infarction, heart failure or coronary revascularization). Multivariable-adjusted risk ratio (RR) with 95% confidence intervals (CI) was pooled for the highest versus the lowest pentraxin-3 group to summarize the predictive value.
Nine studies were included, enrolling 5,174 CAD patients. Overall, CAD patients with the highest pentraxin-3 level had an increased risk of all-cause mortality (RR 1.81; 95% CI 1.43–2.28), cardiac death (RR 1.77; 95% CI 1.38–2.26), and cardiac events (RR 1.61; 95% CI 1.16–2.25). However, elevated pentraxin-3 level appeared to not significantly increase the risk of cardiac events (RR 1.63; 95% CI 0.71–3.72) in stable CAD subgroup.
In CAD patients, elevated circulating pentraxin-3 level is possibly an independent predictor of all-cause mortality, cardiac death, and cardiac events. However, interpretation of these findings should be with caution due to the small number of studies analyzed. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 |
ISSN: | 1043-4666 1096-0023 |
DOI: | 10.1016/j.cyto.2019.03.017 |