Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.

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Published inChemical communications (Cambridge, England) Vol. 52; no. 44; pp. 7114 - 7117
Main Authors Nigam, Shubhanchi, Burke, Benjamin P., Davies, Laura H., Domarkas, Juozas, Wallis, Jennifer F., Waddell, Paul G., Waby, Jennifer S., Benoit, David M., Seymour, Anne-Marie, Cawthorne, Christopher, Higham, Lee J., Archibald, Stephen J.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2016
Subjects
Cancer
Chemistry
Chemistry, Multidisciplinary
Derivatives
Dyes
Imaging
Membranes
Physical Sciences
Science & Technology
Uptakes
FLUORESCENT
POSITRON-EMISSION-TOMOGRAPHY
TARGETING MITOCHONDRIA
RADIOTRACERS
LIPOPHILIC CATIONS
PHOSPHONIUM CATIONS
F-18
PROBES
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Abstract The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.
AbstractList The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.
Author Benoit, David M.
Wallis, Jennifer F.
Davies, Laura H.
Cawthorne, Christopher
Nigam, Shubhanchi
Domarkas, Juozas
Waddell, Paul G.
Seymour, Anne-Marie
Higham, Lee J.
Waby, Jennifer S.
Archibald, Stephen J.
Burke, Benjamin P.
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  givenname: Benjamin P.
  orcidid: 0000-0002-2092-6754
  surname: Burke
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  givenname: Laura H.
  surname: Davies
  fullname: Davies, Laura H.
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  givenname: Juozas
  surname: Domarkas
  fullname: Domarkas, Juozas
  organization: Univ Hull, Positron Emiss Tomog Res Ctr, Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England
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  givenname: Jennifer F.
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  givenname: Jennifer S.
  orcidid: 0000-0003-4729-6657
  surname: Waby
  fullname: Waby, Jennifer S.
  organization: Univ Hull, Sch Biol Biomed & Environm Sci, Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England
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  givenname: David M.
  orcidid: 0000-0002-7773-6863
  surname: Benoit
  fullname: Benoit, David M.
  organization: Univ Hull, Dept Chem, Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England
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  givenname: Anne-Marie
  surname: Seymour
  fullname: Seymour, Anne-Marie
  organization: Univ Hull, Ctr Cardiovasc & Metab Res, Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England
– sequence: 10
  givenname: Christopher
  orcidid: 0000-0002-5975-0354
  surname: Cawthorne
  fullname: Cawthorne, Christopher
  organization: Univ Hull, Positron Emiss Tomog Res Ctr, Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England
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  givenname: Lee J.
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  givenname: Stephen J.
  orcidid: 0000-0001-7581-8817
  surname: Archibald
  fullname: Archibald, Stephen J.
  email: S.J.Archibald@Hull.ac.uk
  organization: Univ Hull, Dept Chem, Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England
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Keywords FLUORESCENT
POSITRON-EMISSION-TOMOGRAPHY
TARGETING MITOCHONDRIA
RADIOTRACERS
LIPOPHILIC CATIONS
PHOSPHONIUM CATIONS
F-18
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Snippet The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of...
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SubjectTerms Cancer
Chemistry
Chemistry, Multidisciplinary
Derivatives
Dyes
Imaging
Membranes
Physical Sciences
Science & Technology
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Title Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells
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