Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 52; no. 44; pp. 7114 - 7117
Main Authors Nigam, Shubhanchi, Burke, Benjamin P., Davies, Laura H., Domarkas, Juozas, Wallis, Jennifer F., Waddell, Paul G., Waby, Jennifer S., Benoit, David M., Seymour, Anne-Marie, Cawthorne, Christopher, Higham, Lee J., Archibald, Stephen J.
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2016
Subjects
Cancer
Chemistry
Chemistry, Multidisciplinary
Derivatives
Dyes
Imaging
Membranes
Physical Sciences
Science & Technology
Uptakes
FLUORESCENT
POSITRON-EMISSION-TOMOGRAPHY
TARGETING MITOCHONDRIA
RADIOTRACERS
LIPOPHILIC CATIONS
PHOSPHONIUM CATIONS
F-18
PROBES
Online AccessGet full text

Cover

More Information
Summary:The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.
Bibliography:researchfish
UKRI
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc08325g