Circular RNAs as novel rising stars with huge potentials in development and disease

Circular RNAs (circRNAs), which were recently discovered as a special class of endogenous non-coding RNAs, have recently shown huge capabilities as gene regulators in different species in a wide variety of organisms including viruses, plants, archaea and animals. These circRNAs mainly arise from exo...

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Published inCancer biomarkers : section A of Disease markers Vol. 22; no. 4; pp. 597 - 610
Main Authors Zhou, Jian, Ge, Yuyuan, Hu, Yun, Rong, Dawei, Fu, Kai, Wang, Hanjin, Cao, Hongyong, Tang, Weiwei
Format Journal Article
LanguageEnglish
Published Netherlands IOS Press BV 01.01.2018
Subjects
Animal diseases
Animals
Archaea
Cytoplasm
Developmental stages
Exons
Gene expression
Introns
Plant viruses
Regulators
Splicing
Viruses
Circular RNA
diagnosis
animals
anti-cancer
botanics
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Summary:Circular RNAs (circRNAs), which were recently discovered as a special class of endogenous non-coding RNAs, have recently shown huge capabilities as gene regulators in different species in a wide variety of organisms including viruses, plants, archaea and animals. These circRNAs mainly arise from exons or introns in different combinations by special selective splicing and are enriched in cytoplasm. Apart from that, circRNAs usually display patterns of cell-type, tissue-type and developmental-stage specific expression in eukaryotic transcriptome. These findings hint at the vital function of circRNAs in development and diseases. Hereinafter, we summarize the current understanding of the molecular characteristics of circRNAs and discuss their proposed functions and mechanism-of-action in human diseases, animals as well as botanics.
Bibliography:ObjectType-Article-2
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ISSN:1574-0153
1875-8592
DOI:10.3233/CBM-181296