Effect of propionate and pyruvate on citrulline synthesis and ATP content in rat liver mitochondria

Propionate inhibits citrullinogenesis when succinate (plus rotenone) or glutamate are the oxidizable substrates used. Propionate decreases the intramitochondrial concentration of carbamylphosphate by decreasing the ATP content. When the energy supply for citrullinogenesis is provided by an influx of...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 90; no. 1; pp. 327 - 332
Main Authors Cathelineau, Liliane, Petit, Françoise P., Coudé, François X, Kamoun, Pierre P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 12.09.1979
Subjects
Adenosine Triphosphate - metabolism
Animals
Citrulline - biosynthesis
Kinetics
Male
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Propionates - pharmacology
Pyruvates - pharmacology
Rats
Rotenone - pharmacology
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Summary:Propionate inhibits citrullinogenesis when succinate (plus rotenone) or glutamate are the oxidizable substrates used. Propionate decreases the intramitochondrial concentration of carbamylphosphate by decreasing the ATP content. When the energy supply for citrullinogenesis is provided by an influx of exogenous ATP, propionate is no longer an inhibitor. Pyruvate inhibits citrullinogenesis with glutamate but not with succinate (plus rotenone) as oxidizable substrates. Propionate and pyruvate deplete mitochondrial ATP but probably by different mechanisms.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(79)91628-0