Synthesis and characterization of new secondary benzylamines derivatives of aryl-himachalene

A simple and efficient synthesis of aryl-himachalene benzylamines derivatives from himachalenes, natural sesquiterpenes isolated from essential oil of Cedrus atlantica , via chloromethylation reaction. Various aromatic amines were used to provide the corresponding secondary benzylamines in good yiel...

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Bibliographic Details
Published inChemical papers Vol. 75; no. 7; pp. 3207 - 3213
Main Authors Ait Lahcen, Intissar, Edder, Youssef, Mallouk, Siham, Boualy, Brahim, Karim, Abdalah
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.07.2021
Springer Nature B.V
Subjects
Amines
Aromatic compounds
Biochemistry
Biotechnology
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Essential oils
Industrial Chemistry/Chemical Engineering
Materials Science
Medicinal Chemistry
Original Paper
Synthesis
Products
Chloromethylation
Benzylamine
Natural
Aryl-himachalene
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Summary:A simple and efficient synthesis of aryl-himachalene benzylamines derivatives from himachalenes, natural sesquiterpenes isolated from essential oil of Cedrus atlantica , via chloromethylation reaction. Various aromatic amines were used to provide the corresponding secondary benzylamines in good yields. The reaction offers a first practical synthetic method for the preparation of a range of sesquiterpenes with benzylamines moiety. Graphic abstract
ISSN:2585-7290
0366-6352
1336-9075
DOI:10.1007/s11696-021-01563-5