Results of a E.O.R.T.C. randomized trial of cyclophosphamide and radiotherapy in inoperable lung cancer: Prognostic factors and treatment results
A randomized cooperative clinical trial has been conducted in inoperable carcinoma of the lung. One hundred and eighty-seven patients under age 72 of both sexes of all cell types were admitted provided they had had no previous surgery, chemotherapy or radiotherapy with the exception that patients ha...
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| Published in | European journal of cancer Vol. 14; no. 9; pp. 919 - 930 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.09.1978
|
| Subjects | |
| Online Access | Get full text |
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| Abstract | A randomized cooperative clinical trial has been conducted in inoperable carcinoma of the lung. One hundred and eighty-seven patients under age
72 of both sexes of all cell types were admitted provided they had had no previous surgery, chemotherapy or radiotherapy with the exception that patients having received less than
2g of cyclophosphamide or less than
2 weeks of chemotherapy of any kind could be included. Treatment was assigned by randomization, stratified by institution and cell type, to one of the following treatments:
(1) continuous radiotherapy (
6000 rad at the rate of
1000 rad per week),
(2) split-course radiotherapy (
3 series of
2000 rad each administered in three
2-week periods separated by
8-week intervals),
(3) continuous radiotherapy plus cyclophosphamide,
(4) split-course radiotherapy plus cyclophosphamide. Cyclophosphamide was given at the dose of
20 mg/kg i.v. or i.m. every
15 days starting
15 days after the completion of continuous radiotherapy or
15 days after the first course of radiotherapy for those receiving the split-dose schedule.
No statistically significant differences in survival were seen between treatment groups. |
|---|---|
| AbstractList | A randomized cooperative clinical trial has been conducted in inoperable carcinoma of the lung. One hundred and eighty-seven patients under age
72 of both sexes of all cell types were admitted provided they had had no previous surgery, chemotherapy or radiotherapy with the exception that patients having received less than
2g of cyclophosphamide or less than
2 weeks of chemotherapy of any kind could be included. Treatment was assigned by randomization, stratified by institution and cell type, to one of the following treatments:
(1) continuous radiotherapy (
6000 rad at the rate of
1000 rad per week),
(2) split-course radiotherapy (
3 series of
2000 rad each administered in three
2-week periods separated by
8-week intervals),
(3) continuous radiotherapy plus cyclophosphamide,
(4) split-course radiotherapy plus cyclophosphamide. Cyclophosphamide was given at the dose of
20 mg/kg i.v. or i.m. every
15 days starting
15 days after the completion of continuous radiotherapy or
15 days after the first course of radiotherapy for those receiving the split-dose schedule.
No statistically significant differences in survival were seen between treatment groups. |
| Author | Laval, P. Kenis, Y. Couette, J.E. Longueville, J. Marion, L. Byar, D. Van Andel, J.G. de Jong, M. |
| Author_xml | – sequence: 1 givenname: D. surname: Byar fullname: Byar, D. organization: Consultant, E.O.R.T.C. Data Center, Institut Jules Bordet, Bruxelles, Belgium. National Cancer Institute, Bethesda, Maryland, U.S.A – sequence: 2 givenname: Y. surname: Kenis fullname: Kenis, Y. organization: Institut Jules Bordet, Bruxelles, Belgium – sequence: 3 givenname: J.G. surname: Van Andel fullname: Van Andel, J.G. organization: Rotterdamsch Radiotherapeutisch Instituut, Rotterdam, The Netherlands – sequence: 4 givenname: M. surname: de Jong fullname: de Jong, M. organization: Rotterdamsch Radiotherapeutisch Instituut, Rotterdam, The Netherlands – sequence: 5 givenname: P. surname: Laval fullname: Laval, P. organization: C.R.A.C.M., Marseille, France – sequence: 6 givenname: L. surname: Marion fullname: Marion, L. organization: Centre Médico-Chirurgical La Musse, Evreux, France – sequence: 7 givenname: J.E. surname: Couette fullname: Couette, J.E. organization: Centre Régional François-Baclesse, Caen, France – sequence: 8 givenname: J. surname: Longueville fullname: Longueville, J. organization: Centre des Tumeurs, Cliniques Universitaires “St. Raphaël”, Louvain, Belgium |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/361416$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/0014-2964(68)90035-2 10.1002/1097-0142(197606)37:6<2658::AID-CNCR2820370613>3.0.CO;2-T 10.2214/ajr.126.1.116 10.1002/1097-0142(197208)30:2<315::AID-CNCR2820300202>3.0.CO;2-E 10.1002/1097-0142(197209)30:3<621::AID-CNCR2820300305>3.0.CO;2-0 10.1002/1097-0142(197701)39:1<303::AID-CNCR2820390147>3.0.CO;2-U 10.1016/0021-9681(58)90126-7 10.1002/1097-0142(197606)37:6<2636::AID-CNCR2820370611>3.0.CO;2-6 10.1002/1097-0142(197606)37:6<2630::AID-CNCR2820370610>3.0.CO;2-R 10.1002/1097-0142(197606)37:6<2671::AID-CNCR2820370615>3.0.CO;2-5 10.1002/1097-0142(194811)1:4<634::AID-CNCR2820010410>3.0.CO;2-L |
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| References_xml | – volume: 37 start-page: 2636 year: 1976 ident: BIB2 article-title: Predictors of radiation response in lung cancer publication-title: Cancer (Philad.) contributor: fullname: Keller – year: 1977 ident: BIB19 publication-title: Second National Cancer Institute Conference on Lung Cancer Treatment – volume: 1 start-page: 634 year: 1948 ident: BIB5 article-title: The use of the nitrogen mustards in the palliative treatment of carcinoma publication-title: Cancer (Philad.) contributor: fullname: Burchenal – volume: 6 start-page: 699 year: 1958 ident: BIB6 article-title: Maximum utilization of the life table method in analyzing survival publication-title: J. chron. Dis. contributor: fullname: Ederer – volume: 50 start-page: 163 year: 1966 ident: BIB7 article-title: Evaluation of survival data and two new rank order statistics arising in its consideration publication-title: Cancer Chemother. Rep. contributor: fullname: Mantel – volume: 30 start-page: 621 year: 1972 ident: BIB13 article-title: Lung cancer: clinical trial of radiotherapy alone vs radiotherapy plus cyclophosphamide publication-title: Cancer (Philad.) contributor: fullname: McDermot – volume: 59 start-page: 377 year: 1975 ident: BIB16 article-title: Combination chemotherapy with bleomycin (NSC-125066), vincristine (NSC-67574), and methotrexate (NSC-740) plus split-course radiotherapy in the treatment of non-oat-cell bronchogenic carcinoma publication-title: Cancer Chemother. Rep. contributor: fullname: Smith – start-page: 191 year: 1977 ident: BIB9 article-title: Combined modality approaches in lung cancer publication-title: Adjuvant Therapy of Cancer contributor: fullname: Livingstone – volume: 37 start-page: 2658 year: 1976 ident: BIB17 article-title: Oat cell carcinoma of the lung publication-title: Cancer (Philad.) contributor: fullname: Furnas – volume: 143 start-page: 154 year: 1972 ident: BIB10 article-title: Strahlentherapie des inoperablen Bronchuskarzinoms in Kombination mit einer Endoxanbehandlung publication-title: Strahlentherapie contributor: fullname: Wieland – volume: 30 start-page: 315 year: 1972 ident: BIB15 article-title: Intensive combined chemotherapy and radiotherapy in patients with nonresectable bronchogenic carcinoma publication-title: Cancer (Philad.) contributor: fullname: Selawry – volume: 4 start-page: 161 year: 1973 ident: BIB12 article-title: Cyclophosphamide (NSC-26271) as adjuvant to radiotherapy in the treatment of unresectable bronchogenic carcinoma publication-title: Cancer Chemother. Rep. contributor: fullname: Host – volume: 37 start-page: 2671 year: 1976 ident: BIB14 article-title: Unresectable squamous cell carcinoma of the lung and its management by combined bleomycin and radiotherapy publication-title: Cancer (Philad.) contributor: fullname: Aronstam – volume: 37 start-page: 2630 year: 1976 ident: BIB1 article-title: Radical irradiation with the split-course technique in carcinoma of the lung publication-title: Cancer (Philad.) contributor: fullname: Caldwell – volume: 126 start-page: 116 year: 1976 ident: BIB3 article-title: Comparison of split-course radiation therapy and continuous radiation therapy for unresectable bronchogenic carcinoma: 5 yr results publication-title: Amer. J. Roentgenol. contributor: fullname: Childs – volume: 58 start-page: 359 year: 1974 ident: BIB11 article-title: Preliminary report on the treatment of nonresectable cancer of the lung publication-title: Cancer Chemother. Rep. contributor: fullname: Zelen – volume: 4 start-page: 31 year: 1973 ident: BIB20 article-title: Keynote address on biostatistics and data retrieval publication-title: Cancer Chemother. Rep. contributor: fullname: Zelen – volume: 4 start-page: 437 year: 1968 ident: BIB4 article-title: Résultats d'un essai thérapeutique clinique sur une association radiothérapie et chimiothérapie dans les cancers bronchopulmonaires publication-title: Europ. J. Cancer – start-page: 37 year: 1975 ident: BIB8 article-title: L'immunothérapie des cancers bronchopulmonaires publication-title: Actualités Cancérol. contributor: fullname: De Wasch – volume: 39 start-page: 303 year: 1977 ident: BIB21 article-title: Survival with inoperable lung cancer—integration of prognostic variables based on simple clinical criteria publication-title: Cancer (Philad.) contributor: fullname: Samuels – start-page: 131 year: 1977 ident: BIB18 article-title: Progress in lung cancer treatment publication-title: Recent Advances in Cancer Treatment contributor: fullname: Kenis – start-page: 191 year: 1977 ident: 10.1016/0014-2964(78)90018-X_BIB9 article-title: Combined modality approaches in lung cancer contributor: fullname: Livingstone – start-page: 131 year: 1977 ident: 10.1016/0014-2964(78)90018-X_BIB18 article-title: Progress in lung cancer treatment contributor: fullname: De Jager – volume: 4 start-page: 31 year: 1973 ident: 10.1016/0014-2964(78)90018-X_BIB20 article-title: Keynote address on biostatistics and data retrieval publication-title: Cancer Chemother. Rep. contributor: fullname: Zelen – volume: 4 start-page: 437 year: 1968 ident: 10.1016/0014-2964(78)90018-X_BIB4 article-title: Résultats d'un essai thérapeutique clinique sur une association radiothérapie et chimiothérapie dans les cancers bronchopulmonaires publication-title: Europ. J. Cancer doi: 10.1016/0014-2964(68)90035-2 – start-page: 37 year: 1975 ident: 10.1016/0014-2964(78)90018-X_BIB8 article-title: L'immunothérapie des cancers bronchopulmonaires publication-title: Actualités Cancérol. contributor: fullname: Kenis – year: 1977 ident: 10.1016/0014-2964(78)90018-X_BIB19 – volume: 58 start-page: 359 year: 1974 ident: 10.1016/0014-2964(78)90018-X_BIB11 article-title: Preliminary report on the treatment of nonresectable cancer of the lung publication-title: Cancer Chemother. Rep. contributor: fullname: Kaung – volume: 59 start-page: 377 year: 1975 ident: 10.1016/0014-2964(78)90018-X_BIB16 article-title: Combination chemotherapy with bleomycin (NSC-125066), vincristine (NSC-67574), and methotrexate (NSC-740) plus split-course radiotherapy in the treatment of non-oat-cell bronchogenic carcinoma publication-title: Cancer Chemother. Rep. contributor: fullname: Samuels – volume: 37 start-page: 2658 year: 1976 ident: 10.1016/0014-2964(78)90018-X_BIB17 article-title: Oat cell carcinoma of the lung publication-title: Cancer (Philad.) doi: 10.1002/1097-0142(197606)37:6<2658::AID-CNCR2820370613>3.0.CO;2-T contributor: fullname: Hornback – volume: 4 start-page: 161 year: 1973 ident: 10.1016/0014-2964(78)90018-X_BIB12 article-title: Cyclophosphamide (NSC-26271) as adjuvant to radiotherapy in the treatment of unresectable bronchogenic carcinoma publication-title: Cancer Chemother. Rep. contributor: fullname: Host – volume: 50 start-page: 163 year: 1966 ident: 10.1016/0014-2964(78)90018-X_BIB7 article-title: Evaluation of survival data and two new rank order statistics arising in its consideration publication-title: Cancer Chemother. Rep. contributor: fullname: Mantel – volume: 143 start-page: 154 year: 1972 ident: 10.1016/0014-2964(78)90018-X_BIB10 article-title: Strahlentherapie des inoperablen Bronchuskarzinoms in Kombination mit einer Endoxanbehandlung publication-title: Strahlentherapie contributor: fullname: Scheurlen – volume: 126 start-page: 116 year: 1976 ident: 10.1016/0014-2964(78)90018-X_BIB3 article-title: Comparison of split-course radiation therapy and continuous radiation therapy for unresectable bronchogenic carcinoma: 5 yr results publication-title: Amer. J. Roentgenol. doi: 10.2214/ajr.126.1.116 contributor: fullname: Lee – volume: 30 start-page: 315 year: 1972 ident: 10.1016/0014-2964(78)90018-X_BIB15 article-title: Intensive combined chemotherapy and radiotherapy in patients with nonresectable bronchogenic carcinoma publication-title: Cancer (Philad.) doi: 10.1002/1097-0142(197208)30:2<315::AID-CNCR2820300202>3.0.CO;2-E contributor: fullname: Hansen – volume: 30 start-page: 621 year: 1972 ident: 10.1016/0014-2964(78)90018-X_BIB13 article-title: Lung cancer: clinical trial of radiotherapy alone vs radiotherapy plus cyclophosphamide publication-title: Cancer (Philad.) doi: 10.1002/1097-0142(197209)30:3<621::AID-CNCR2820300305>3.0.CO;2-0 contributor: fullname: Bergsagel – volume: 39 start-page: 303 year: 1977 ident: 10.1016/0014-2964(78)90018-X_BIB21 article-title: Survival with inoperable lung cancer—integration of prognostic variables based on simple clinical criteria publication-title: Cancer (Philad.) doi: 10.1002/1097-0142(197701)39:1<303::AID-CNCR2820390147>3.0.CO;2-U contributor: fullname: Lanzotti – volume: 6 start-page: 699 year: 1958 ident: 10.1016/0014-2964(78)90018-X_BIB6 article-title: Maximum utilization of the life table method in analyzing survival publication-title: J. chron. Dis. doi: 10.1016/0021-9681(58)90126-7 contributor: fullname: Cutler – volume: 37 start-page: 2636 year: 1976 ident: 10.1016/0014-2964(78)90018-X_BIB2 article-title: Predictors of radiation response in lung cancer publication-title: Cancer (Philad.) doi: 10.1002/1097-0142(197606)37:6<2636::AID-CNCR2820370611>3.0.CO;2-6 contributor: fullname: Salazar – volume: 37 start-page: 2630 year: 1976 ident: 10.1016/0014-2964(78)90018-X_BIB1 article-title: Radical irradiation with the split-course technique in carcinoma of the lung publication-title: Cancer (Philad.) doi: 10.1002/1097-0142(197606)37:6<2630::AID-CNCR2820370610>3.0.CO;2-R contributor: fullname: Aristizabal – volume: 37 start-page: 2671 year: 1976 ident: 10.1016/0014-2964(78)90018-X_BIB14 article-title: Unresectable squamous cell carcinoma of the lung and its management by combined bleomycin and radiotherapy publication-title: Cancer (Philad.) doi: 10.1002/1097-0142(197606)37:6<2671::AID-CNCR2820370615>3.0.CO;2-5 contributor: fullname: Chan – volume: 1 start-page: 634 year: 1948 ident: 10.1016/0014-2964(78)90018-X_BIB5 article-title: The use of the nitrogen mustards in the palliative treatment of carcinoma publication-title: Cancer (Philad.) doi: 10.1002/1097-0142(194811)1:4<634::AID-CNCR2820010410>3.0.CO;2-L contributor: fullname: Karnofsky |
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| Snippet | A randomized cooperative clinical trial has been conducted in inoperable carcinoma of the lung. One hundred and eighty-seven patients under age
72 of both... |
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| SubjectTerms | Adult Aged Carcinoma, Bronchogenic - drug therapy Carcinoma, Bronchogenic - radiotherapy Carcinoma, Bronchogenic - therapy Clinical Trials as Topic Cyclophosphamide - therapeutic use Europe Female Humans Lung Neoplasms - drug therapy Lung Neoplasms - radiotherapy Lung Neoplasms - therapy Male Middle Aged Prognosis Radiotherapy Dosage Random Allocation Remission, Spontaneous Risk |
| Title | Results of a E.O.R.T.C. randomized trial of cyclophosphamide and radiotherapy in inoperable lung cancer: Prognostic factors and treatment results |
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