Results of a E.O.R.T.C. randomized trial of cyclophosphamide and radiotherapy in inoperable lung cancer: Prognostic factors and treatment results
A randomized cooperative clinical trial has been conducted in inoperable carcinoma of the lung. One hundred and eighty-seven patients under age 72 of both sexes of all cell types were admitted provided they had had no previous surgery, chemotherapy or radiotherapy with the exception that patients ha...
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Published in | European journal of cancer Vol. 14; no. 9; pp. 919 - 930 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.09.1978
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Subjects | |
Online Access | Get full text |
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Summary: | A randomized cooperative clinical trial has been conducted in inoperable carcinoma of the lung. One hundred and eighty-seven patients under age
72 of both sexes of all cell types were admitted provided they had had no previous surgery, chemotherapy or radiotherapy with the exception that patients having received less than
2g of cyclophosphamide or less than
2 weeks of chemotherapy of any kind could be included. Treatment was assigned by randomization, stratified by institution and cell type, to one of the following treatments:
(1) continuous radiotherapy (
6000 rad at the rate of
1000 rad per week),
(2) split-course radiotherapy (
3 series of
2000 rad each administered in three
2-week periods separated by
8-week intervals),
(3) continuous radiotherapy plus cyclophosphamide,
(4) split-course radiotherapy plus cyclophosphamide. Cyclophosphamide was given at the dose of
20 mg/kg i.v. or i.m. every
15 days starting
15 days after the completion of continuous radiotherapy or
15 days after the first course of radiotherapy for those receiving the split-dose schedule.
No statistically significant differences in survival were seen between treatment groups. |
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ISSN: | 0014-2964 |
DOI: | 10.1016/0014-2964(78)90018-X |