Propionate and succinate effects on acetyl glutamate biosynthesis by rat liver mitochondria

Acetylglutamate biosynthesis in isolated rat liver mitochondria is dependent on glutamate and stimulated by arginine. Propionate and succinate inhibit this glutamate-dependent synthesis and their effects seem to be cumulative.

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 91; no. 2; pp. 456 - 460
Main Authors Rabier, D., Cathelineau, L., Briand, P., Kamoun, P.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 28.11.1979
Subjects
Animals
Bicarbonates - metabolism
Glutamates - biosynthesis
Kinetics
Male
Mitochondria, Liver - drug effects
Mitochondria, Liver - metabolism
Propionates - pharmacology
Rats
Succinates - pharmacology
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Summary:Acetylglutamate biosynthesis in isolated rat liver mitochondria is dependent on glutamate and stimulated by arginine. Propionate and succinate inhibit this glutamate-dependent synthesis and their effects seem to be cumulative.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(79)91543-2