Circulating MIC-1/GDF15 is a complementary screening biomarker with CEA and correlates with liver metastasis and poor survival in colorectal cancer

Macrophage inhibitory cytokine 1 (MIC-1/GDF15) has been characterized as a candidate biomarker for colorectal cancer (CRC) recently. However, the role of serum MIC-1 in screening patients with early stage CRC and monitoring therapeutic response have not been well-established, particularly in the com...

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Published inOncotarget Vol. 8; no. 15; pp. 24892 - 24901
Main Authors Wang, Xiaobing, Yang, Zhaogang, Tian, Haimei, Li, Yanfen, Li, Mo, Zhao, Wenya, Zhang, Chao, Wang, Teng, Liu, Jing, Zhang, Aili, Shen, Di, Zheng, Cuining, Qi, Jun, Zhao, Dan, Shi, Junfeng, Jin, Liliang, Rao, Jianyu, Zhang, Wei
Format Journal Article
LanguageEnglish
Published United States Impact Journals LLC 11.04.2017
Subjects
Biomarkers, Tumor - blood
Carcinoembryonic Antigen - blood
Colorectal Neoplasms - blood
Colorectal Neoplasms - pathology
Female
Growth Differentiation Factor 15 - blood
Humans
Male
Middle Aged
Neoplasm Metastasis
Prognosis
Research Paper
Survival Analysis
liver metastasis
screening
colorectal cancer
biomarker
prognosis
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Abstract Macrophage inhibitory cytokine 1 (MIC-1/GDF15) has been characterized as a candidate biomarker for colorectal cancer (CRC) recently. However, the role of serum MIC-1 in screening patients with early stage CRC and monitoring therapeutic response have not been well-established, particularly in the combination with CEA for the screening and the prejudgment of occurrence with liver metastasis. In this study, we performed a retrospective blinded evaluation of 987 serum samples from 473 individuals with CRC, 25 with adenomatous polyps, and 489 healthy individuals using ELISA or immunoassay. The sensitivity of serum MIC-1 was 43.8% and 38.5% for CRC diagnosis and early diagnosis, respectively, which were independent of and comparatively higher than for CEA (36.6% and 27.3%) at comparable specificity. Serum MIC-1 after surgery were significantly elevated at the time of tumor recurrence, and notable increase were observed in 100% patients with liver metastasis. Besides the TNM classification and differentiation grade, MIC-1 was an independent prognostic factor contributing to overall survival. We conclude that MIC-1 can act as a candidate complementary biomarker for screening early-stage CRC by combination with CEA, and furthermore, for the first time, identify a promising prognostic indicator for monitoring recurrence with liver metastasis, to support strategies towards personalized therapy.
AbstractList Macrophage inhibitory cytokine 1 (MIC-1/GDF15) has been characterized as a candidate biomarker for colorectal cancer (CRC) recently. However, the role of serum MIC-1 in screening patients with early stage CRC and monitoring therapeutic response have not been well-established, particularly in the combination with CEA for the screening and the prejudgment of occurrence with liver metastasis. In this study, we performed a retrospective blinded evaluation of 987 serum samples from 473 individuals with CRC, 25 with adenomatous polyps, and 489 healthy individuals using ELISA or immunoassay. The sensitivity of serum MIC-1 was 43.8% and 38.5% for CRC diagnosis and early diagnosis, respectively, which were independent of and comparatively higher than for CEA (36.6% and 27.3%) at comparable specificity. Serum MIC-1 after surgery were significantly elevated at the time of tumor recurrence, and notable increase were observed in 100% patients with liver metastasis. Besides the TNM classification and differentiation grade, MIC-1 was an independent prognostic factor contributing to overall survival. We conclude that MIC-1 can act as a candidate complementary biomarker for screening early-stage CRC by combination with CEA, and furthermore, for the first time, identify a promising prognostic indicator for monitoring recurrence with liver metastasis, to support strategies towards personalized therapy.
Author Zhang, Aili
Zheng, Cuining
Tian, Haimei
Liu, Jing
Rao, Jianyu
Zhang, Wei
Wang, Xiaobing
Wang, Teng
Shi, Junfeng
Zhao, Dan
Zhao, Wenya
Yang, Zhaogang
Shen, Di
Zhang, Chao
Qi, Jun
Li, Yanfen
Jin, Liliang
Li, Mo
AuthorAffiliation 4 Department of Gynecological Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
5 Department of Mechanical Engineering, The Ohio State University, Columbus, OH, USA
3 Laboratory of Clinical Biochemistry, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
2 NSF Nanoscale Science and Engineering Center (NSEC), The Ohio State University, Columbus, OH, USA
6 Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA, USA
1 Tumor Marker Research Center, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
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  organization: Tumor Marker Research Center, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
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Issue 15
Keywords liver metastasis
screening
colorectal cancer
biomarker
prognosis
Language English
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Snippet Macrophage inhibitory cytokine 1 (MIC-1/GDF15) has been characterized as a candidate biomarker for colorectal cancer (CRC) recently. However, the role of serum...
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SubjectTerms Biomarkers, Tumor - blood
Carcinoembryonic Antigen - blood
Colorectal Neoplasms - blood
Colorectal Neoplasms - pathology
Female
Growth Differentiation Factor 15 - blood
Humans
Male
Middle Aged
Neoplasm Metastasis
Prognosis
Research Paper
Survival Analysis
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Title Circulating MIC-1/GDF15 is a complementary screening biomarker with CEA and correlates with liver metastasis and poor survival in colorectal cancer
URI https://www.ncbi.nlm.nih.gov/pubmed/28206963
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