Involvement of a battery of investigated genes in lipid droplet pathophysiology and associated comorbidities

• Published in: Adipocyte Vol. 13; no. 1; p. 2403380
• Main Authors: Al Harake, Sami N, Abedin, Yasamin, Hatoum, Fatema, Nassar, Nour Zahraa, Ali, Ali, Nassar, Aline, Kanaan, Amjad, Bazzi, Samer, Azar, Sami, Harb, Frederic, Ghadieh, Hilda E
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2024; Taylor & Francis Group
• Subjects: Adipocytes - metabolism; adipogenesis; Adipose Tissue, White - metabolism; Animals; Comorbidity; Humans; Insulin Resistance; Lipid droplet formation; lipid droplet hydrolysis; Lipid Droplets - metabolism; Lipid Metabolism - genetics; lipodystrophy; Lipodystrophy - genetics; Lipodystrophy - metabolism; Mutation; Review; Lipid droplet formation; adipogenesis; insulin resistance; lipid droplet hydrolysis; lipodystrophy
• ISSN: 2162-3945; 2162-397X; 2162-397X
• DOI: 10.1080/21623945.2024.2403380

Lipid droplets (LDs) are highly specialized energy storage organelles involved in the maintenance of lipid homoeostasis by regulating lipid flux within white adipose tissue (WAT). The physiological function of adipocytes and LDs can be compromised by mutations in several genes, leading to NEFA-induced lipotoxicity, which ultimately manifests as metabolic complications, predominantly in the form of dyslipidemia, ectopic fat accumulation, and insulin resistance. In this review, we delineate the effects of mutations and deficiencies in genes - , , , , , , , , , and - involved in lipid droplet metabolism and their associated pathophysiological impairments, highlighting their roles in the development of lipodystrophies and metabolic dysfunction.