Generational stability of epigenetic transgenerational inheritance facilitates adaptation and evolution

• Published in: Epigenetics Vol. 19; no. 1; p. 2380929
• Main Authors: Korolenko, Alexandra, Skinner, Michael K
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2024; Taylor & Francis Group
• Subjects: adaptation; Adaptation, Physiological - genetics; Animals; Biological Evolution; DNA Methylation; Epigenesis, Genetic; Epigenetic; Evolution, Molecular; evolutionary biology; generational stability; Humans; inheritance; Inheritance Patterns; Phenotype; Review; Selection, Genetic; transgenerational; generational stability; evolutionary biology; review; transgenerational; adaptation; inheritance; Epigenetic
• ISSN: 1559-2294; 1559-2308; 1559-2308
• DOI: 10.1080/15592294.2024.2380929

The epigenome and epigenetic inheritance were not included in the original modern synthesis theory or more recent extended evolutionary synthesis of evolution. In a broad range of species, the environment has been shown to play a significant role in natural selection, which more recently has been shown to occur through epigenetic alterations and epigenetic inheritance. However, even with this evidence, the field of epigenetics and epigenetic inheritance has been left out of modern evolutionary synthesis, as well as other current evolutionary models. Epigenetic mechanisms can direct the regulation of genetic processes (e.g. gene expression) and also can be directly changed by the environment. In contrast, DNA sequence cannot be directly altered by the environment. The goal of this review is to present the evidence of how epigenetics and epigenetic inheritance can alter phenotypic variation in numerous species. This can occur at a significantly higher frequency than genetic change, so correlates with the frequency of evolutionary change. In addition, the concept and importance of generational stability of transgenerational inheritance is incorporated into evolutionary theory. For there to be a better understanding of evolutionary biology, we must incorporate all aspects of molecular (e.g. genetics and epigenetics) and biological sciences (e.g. environment and adaptation).