Assessment of cyclin D1 overexpression as a prognostic factor in soft tissue sarcomas : Role of laparoscopy and core needle biopsy

• Published in: Surgical endoscopy Vol. 19; no. 8; pp. 1120 - 1124
• Main Authors: MUSELLA, M, FAZIOLI, F, LOMBARDI, S, SERVODIO, C. I, DE MARTINO, C, IACONO, V, CIGALA, F, JOVINO, R
• Format: Journal Article
• Language: English
• Published: New York, NY Springer 01.08.2005; Springer Nature B.V
• Subjects: Biological and medical sciences; Biopsy; Biopsy, Needle; Cell cycle; Cyclin D1 - biosynthesis; Dermatology; Digestive system. Abdomen; Endoscopy; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Laparoscopy; Male; Medical prognosis; Medical sciences; Metastasis; Middle Aged; Patients; Prognosis; Sarcoma; Sarcoma - metabolism; Sarcoma - mortality; Sarcoma - pathology; Sarcoma - surgery; Soft Tissue Neoplasms - metabolism; Soft Tissue Neoplasms - mortality; Soft Tissue Neoplasms - pathology; Soft Tissue Neoplasms - surgery; Surgery; Survival Rate; Tumors; Tumors of the skin and soft tissue. Premalignant lesions; Cyclin Dl; Prognosis; Biopsy; Needle; Cyclin; Soft tissue sarcoma; Laparoscopy; Preoperative staging; Malignant tumor; Endoscopy; Preoperative; Soft tissue sarcomas
• ISSN: 0930-2794; 1432-2218
• DOI: 10.1007/s00464-004-2094-6

This study was designed to test cyclin D1 as a prognostic marker in patients with soft tissue sarcomas (STS), and to evaluate the usefulness of laparoscopy for determining cyclin D1 overexpression. The records of 62 patients with STS were collected: 28 with retroperitoneal STS (RSTS) and 34 with extremity STS (ESTS). A total of 51 patients underwent surgical resection, whereas 11 did not undergo surgery because of advanced tumor stage. Preoperative-intraoperative laparoscopic staging was performed for patients judged to be resectable at preoperative imaging. Cyclin D1 was overexpressed in 30 (58.8%) of 51 resected patients and in 10 (90.9%) of 11 nonresected patients. Laparoscopy avoided unnecessary laparotomy in 9 (32.1%) of 28 RSTS patients. High tumor grade, positive surgical margins, local recurrence, distant metastases, and cyclin D1 overexpression were related to poor survival. Multivariate analysis demonstrated cyclin D1 to be the only independent factor. Laparoscopy was shown to be useful for avoiding useless laparotomies.