Age-related bone diseases: Role of inflammaging

• Published in: Journal of autoimmunity Vol. 143; p. 103169
• Main Authors: Bi, Jiaming, Zhang, Caimei, Lu, Caihong, Mo, Chuzi, Zeng, Jiawei, Yao, Mingyan, Jia, Bo, Liu, Zhongjun, Yuan, Peiyan, Xu, Shuaimei
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2024
• Subjects: Aging; Aging-related diseases; Bone; Cell senescence; Inflammaging; Aging; Inflammaging; Cell senescence; Bone; Aging-related diseases
• ISSN: 0896-8411; 1095-9157
• DOI: 10.1016/j.jaut.2024.103169

Bone aging is characterized by an imbalance in the physiological and pathological processes of osteogenesis, osteoclastogenesis, adipogenesis, and chondrogenesis, resulting in exacerbated bone loss and the development of age-related bone diseases, including osteoporosis, osteoarthritis, rheumatoid arthritis, and periodontitis. Inflammaging, a novel concept in the field of aging research, pertains to the persistent and gradual escalation of pro-inflammatory reactions during the aging process. This phenomenon is distinguished by its low intensity, systemic nature, absence of symptoms, and potential for management. The mechanisms by which inflammaging contribute to age-related chronic diseases, particularly in the context of age-related bone diseases, remain unclear. The precise manner in which systemic inflammation induces bone aging and consequently contributes to the development of age-related bone diseases has yet to be fully elucidated. This article primarily examines the mechanisms underlying inflammaging and its association with age-related bone diseases, to elucidate the potential mechanisms of inflammaging in age-related bone diseases and offer insights for developing preventive and therapeutic strategies for such conditions. The relationship between inflammaging and age-related bone diseases. The dysregulation of pro-inflammatory and anti-inflammatory networks during inflammaging can disrupt the equilibrium between osteoblasts and osteoclasts, leading to the onset and progression of age-related bone disorders, such as osteoporosis, osteoarthritis, rheumatoid arthritis, and periodontal disease. [Display omitted] •The progression of bone aging may lead to the occurrence of age-related bone disease.•Some processes of cell senescence induce a chronic low-level inflammatory state, namely inflammaging.•Inflammaging hinders tissue repair and regeneration in age-related physiological changes.•Targets related to inflammaging may be a new idea for the treatment of age-related bone diseases.