Efficacy and safety of Resina Draconis for wound repair in the treatment of diabetic foot ulcer: A systematic review and meta-analysis of randomized controlled trials

• Published in: Complementary therapies in clinical practice Vol. 50; p. 101707
• Main Authors: Feng, Haoyue, Huang, Wenhui, Zhou, Qi, Liu, Tianyi, Li, Hui, Yue, Rensong
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2023
• Subjects: China; Diabetes Mellitus; Diabetic Foot - therapy; Diabetic foot ulcer; Humans; Meta-analysis; Randomized controlled trials; Randomized Controlled Trials as Topic; Resina draconis; Systematic review; Ulcer; Wound Healing; China; Systematic review; Resina draconis; Diabetic foot ulcer; Meta-analysis; Randomized controlled trials
• ISSN: 1744-3881; 1873-6947
• DOI: 10.1016/j.ctcp.2022.101707

Resina Draconis (RD) is widely used to treat topical skin ulcers. However, its effect on diabetic foot ulcer (DFU) remains unknown. The present meta-analysis aims to evaluate the efficacy and safety of RD for wound healing in DFU treatment. Literature searches were conducted with databases including PubMed, Embase, Cochrane Library, the China National Knowledge Infrastructure, the Wanfang Database, the Database for Chinese Technical Periodicals, and the China Biology Medicine Disc. Relevant studies were selected based on specified inclusion and exclusion criteria. Software RevMan 5.4 was used for study selection, quality assessment, and data analysis, while the Cochrane Risk of Bias (RoB) 2.0 tool was used to assess RoB. Nine eligible randomized controlled trials (RCTs), involving 679 patients, were included in this review. The results showed that the healing time of the RD group was shorter than that of the control group (P < 0.00001), while the RD group also presented a higher healing rate (P < 0.0001), a higher rate of ulcer area reduction (P = 0.0005), and a higher rate in the patients with a reduced Wagner grade (P = 0.002). Simultaneously, a lower frequency of dressing changes (P < 0.00001) and a shorter length of hospital stays (P < 0.00001) are the characteristics of the RD group as well. The treatment with RD is a safe and effective solution for DFU, and its combination with conventional treatment can improve the healing rate of DFU, reduce healing time, and inhibit further development. However, owing to the limited quality and quantity of included studies, further high-quality research is necessary to support these conclusions. •Topical application of Resina Draconis is an effective adjunct in the treatment of patients with diabetic foot ulcers.•For diabetic patients with ulcers in Wagner grades 1 to 3, Resina Draconis is more beneficial.•In patients with diabetes, Resina Draconis combined with antibiotics tended to be more effective for ulcer repair.