The ratio of factor VIII-related antigen and factor VIII biological activity as an index of hypercoagulability and intravascular clotting

It is suggested that the ratio of factor VIII-related antigen/factor VIII biological activity may be a useful indicator of hypercoagulability or intravascular coagulation, and a measure of the efficacy of steady state anticoagulation. The ratio was shown to progressively increase during normal pregn...

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Published inThrombosis research Vol. 10; no. 1; pp. 107 - 119
Main Author Denson, K.W.E.
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 1977
Subjects
Antigens
Blood Coagulation Factors
Factor VIII - immunology
Female
Humans
Pre-Eclampsia - blood
Pregnancy
Surgical Procedures, Operative
Thrombosis - blood
von Willebrand Factor
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Summary:It is suggested that the ratio of factor VIII-related antigen/factor VIII biological activity may be a useful indicator of hypercoagulability or intravascular coagulation, and a measure of the efficacy of steady state anticoagulation. The ratio was shown to progressively increase during normal pregnancy and was significantly greater in preeclampsia. The ratio increased without exception in ten patients following abdominal surgery and was usually maximal after 1 to 3 days. The ratio was raised in patients with thromboembolic disease, and decreased in all patients following treatment with warfarin or heparin. In 26 out of 28 patients on warfarin therapy for more than 10 days, the ratio was still greater than one.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0049-3848
1879-2472
DOI:10.1016/0049-3848(77)90084-6