Electrochemical Properties of some Transition Metal Complexes: Synthesis, Characterization and In-vitro antimicrobial studies of Co(II), Ni(II), Cu(II), Mn(II) and Fe(III) Complexes

• Published in: International journal of electrochemical science Vol. 4; no. 5; pp. 717 - 729
• Main Authors: Kulkarni, Ajaykumar D., Patil, Sangamesh A., Badami, Prema S.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.05.2009
• Subjects: Electrochemistry; Isatin; Spectral characterization; Transition metals; Electrochemistry; Transition metals; Spectral characterization; Isatin
• ISSN: 1452-3981; 1452-3981
• DOI: 10.1016/S1452-3981(23)15177-7

A series of first complexes of Co(II), Ni(II), Cu(II), Mn(II) and Fe(III) have been synthesized with Schiff base derived from isatin monohydrazone and fluvastatin. The complexes have been characterized in the light of elemental analyses, spectral (IR, Uv-Vis., FAB-mass and ESR) and magnetic studies. The elemental analyses of the complexes confine to the stoichiometry of the type ML2.2Cl [M=Co(II), Ni(II), Cu(II) and Mn(II)] and [FeL2.2Cl]Cl. The redox properties of the complexes were extensively investigated by electrochemical method using cyclic voltammetry (CV). The Co(II) and Cu(II) complexes exhibited quasi-reversible single electron transfer process where as Mn(II) and Fe(III) complexes shown two redox peaks of quasi-reversible one electron transfer process. The Schiff bases and their complexes have been screened for their in-vitro antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus subtilis) and antifungal (Aspergillus niger and Pencillium Chrysogenum) activities by minimum inhibitory concentration (MIC) method.