Intravenous hyperalimentation as an adjunct to cancer chemotherapy with 5-fluorouracil

In a series of 30 male Sprague-Dawley rats fed orally, the LD-80 dosage of 5-FU was determined to be 15 mg/kg/day for 7 days. When this dosage was given to a series of rats nourished entirely parenterally by intravenous hyperalimentation, there was a lower incidence of gastrointestinal toxicity, and...

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Bibliographic Details
Published inThe Journal of surgical research Vol. 18; no. 4; pp. 451 - 454
Main Authors Souchon, Eduardo A., Copeland, Edward M., Watson, Patti, Dudrick, Stanley J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.1975
Subjects
Adenocarcinoma - drug therapy
Adenocarcinoma - therapy
Animals
Colonic Neoplasms - drug therapy
Colonic Neoplasms - therapy
Digestive System - drug effects
Fluorouracil - administration & dosage
Fluorouracil - therapeutic use
Fluorouracil - toxicity
Humans
Male
Neoplasms - drug therapy
Parenteral Nutrition
Parenteral Nutrition, Total
Rats
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Summary:In a series of 30 male Sprague-Dawley rats fed orally, the LD-80 dosage of 5-FU was determined to be 15 mg/kg/day for 7 days. When this dosage was given to a series of rats nourished entirely parenterally by intravenous hyperalimentation, there was a lower incidence of gastrointestinal toxicity, and the mean survival rate was twice that obtained in the orally fed group. In a pilot series of 10 cachectic human beings with metastatic adenocarcinoma of the colon, who were treated simultaneously with 5-FU and intravenous hyperalimentation, the incidence of gastrointestinal side effects was significantly reduced, tolerance to 5-FU per unit time was doubled, and response rate (50% reduction in measurable tumor mass) was 40%, which is greater than that usually reported in comparable patients fed by mouth.
ISSN:0022-4804
1095-8673
DOI:10.1016/0022-4804(75)90108-0