Ras isoforms selectively regulate antigen-specific immune response

•Ras isoforms regulate antigen-specific immune responses.•H-/K-Ras induce Th1 response whereas N-Ras induces Th2 response.•Ras isoform-specific immunotherapy seems feasible. H-/K-Ras and N-Ras isoforms were proposed to lack functional specificities due to similarity in 1–165 amino acids. As recent s...

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Published inCytokine (Philadelphia, Pa.) Vol. 126; p. 154914
Main Authors Jha, Mukesh Kumar, Sarode, Aditya Y., Saha, Bhaskar
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2020
Subjects
Cytokine
Leishmania
Ras GTPase
Ras isoforms
TNP-Ova
Inf
TNP-Ova
IFA
Cytokine
IP
Ctrl
SC
CV
TNP-Ficoll
Leishmania
TNP-LPS
Ras isoforms
TNP-BSA
Ras GTPase
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Summary:•Ras isoforms regulate antigen-specific immune responses.•H-/K-Ras induce Th1 response whereas N-Ras induces Th2 response.•Ras isoform-specific immunotherapy seems feasible. H-/K-Ras and N-Ras isoforms were proposed to lack functional specificities due to similarity in 1–165 amino acids. As recent studies implied Ras isoform-specific developmental effects, we examined their functional specificity using Leishmania major infection, anti-hapten antibody response and carrier-specific T cell response. While N-Ras overexpression increased L. major infection in resistant C57BL/6 mice, H-Ras or K-Ras overexpression reduced the infection in susceptible BALB/c mice. These Ras isoforms differentially regulated anti-TNP antibody response in TNP-Ova-primed, but not in TNP-Ficoll- or TNP-LPS-primed, BALB/c mice. Ras isoform-specific silencing selectively modulated Ova-specific T cell response. The data indicate Ras isoform-specific regulation of antigen-specific immune response.
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ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2019.154914