ADH1B and CDH1 polymorphisms predict prognosis in male patients with non-metastatic laryngeal cancer

• Published in: Oncotarget Vol. 7; no. 45; pp. 73216 - 73228
• Main Authors: Li, Daxu, Zhang, Ruizhi, Jin, Tianbo, He, Na, Ren, Le, Zhang, Zhe, Zhang, Qingna, Xu, Ran, Tao, Hong, Zeng, Guang, Gao, Jing
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 08.11.2016
• Subjects: Adult; Aged; Aged, 80 and over; Alcohol Dehydrogenase - genetics; Alleles; Cadherins - genetics; Genetic Predisposition to Disease; Genotype; Humans; Kaplan-Meier Estimate; Laryngeal Neoplasms - genetics; Laryngeal Neoplasms - mortality; Laryngeal Neoplasms - pathology; Laryngeal Neoplasms - surgery; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Polymorphism, Single Nucleotide; Prognosis; Proportional Hazards Models; Research Paper; Sex Factors; laryngeal cancer; polymorphism; ADH1B; CDH1; prognosis
• ISSN: 1949-2553; 1949-2553
• DOI: 10.18632/oncotarget.12301

In this study, we assessed the association between single nucleotide polymorphisms (SNPs) in candidate genes and the prognosis of laryngeal cancer (LC) patients. Thirty-seven SNPs in 26 genes were genotyped in 170 male Han Chinese patients with LC. The effects of the candidate genes on the prognosis of LC patients were evaluated using Kaplan-Meier curves and Cox proportional hazards regression models. The GA genotype of rs1229984 (hazard ratio [HR], 0.537; 95% confidence interval [CI], 0.340-0.848; p = 0.008) in alcohol dehydrogenase 1B (ADH1B), and the AA genotype of rs9929218 (HR, 6.074; 95% CI, 1.426-25.870; p = 0.015) in CDH1 were associated with overall survival. Our data suggest that polymorphisms in ADH1B and CDH1 may be prognostic indicators in LC.