Catalyst-free synthesis of borodepsipeptides using isocyano arylboronate under aqueous condition

Herein, the synthesis of borodepsipeptides utilizing boron-containing isocyanides is described. The target compounds were synthesized via Passerini three-component reaction (P-3CR), in which H 2 O was utilized as the solvent. Further, unlike conventional P-3CR, where Lewis acid catalysts are often r...

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Published inResearch on chemical intermediates Vol. 46; no. 11; pp. 4841 - 4851
Main Authors Chiang, Yao-Yu, Kuo, Yi-Chen, Lin, Sung-Chi, Yeh, Pei-Yin, Chen, Yi-Wei, Pan, Po-Shen
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.11.2020
Springer Nature
Springer Nature B.V
Subjects
Aldehydes
Boron compounds
Catalysis
Catalysts
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry, Multidisciplinary
Inorganic Chemistry
Lewis acid
Physical Chemistry
Physical Sciences
Room temperature
Science & Technology
No catalyst
Multicomponent reaction
Passerini
Isocyano-boronate esters
Room temperature
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Summary:Herein, the synthesis of borodepsipeptides utilizing boron-containing isocyanides is described. The target compounds were synthesized via Passerini three-component reaction (P-3CR), in which H 2 O was utilized as the solvent. Further, unlike conventional P-3CR, where Lewis acid catalysts are often required, the reported method requires no catalyst and proceeds in room temperature. A variety of aldehydes and acids were used as the building blocks to generate the desired products.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-020-04245-1