Cytogenetic studies in patients treated with penicillamine

Cytogenetic studies were performed on bone-marrow cells from 11 patients with rheumatoid arthritis treated with penicillamine. One of the patients was studied while developing a granulocytopenia and thrombocytopenia. The findings show that penicillamine had no chromosome-damaging effect as estimated...

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Bibliographic Details
Published inMutation Research/Genetic Toxicology Vol. 67; no. 4; pp. 357 - 359
Main Authors Jensen, Mogens Krogh, Rasmussen, Glen Gorm, Ingeberg, Steen
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.08.1979
Subjects
Arthritis, Rheumatoid - drug therapy
Bone Marrow - ultrastructure
Chromosome Aberrations
Chromosomes, Human - drug effects
Dose-Response Relationship, Drug
Female
Genetic Techniques
Humans
Male
Penicillamine - pharmacology
Penicillamine - therapeutic use
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Summary:Cytogenetic studies were performed on bone-marrow cells from 11 patients with rheumatoid arthritis treated with penicillamine. One of the patients was studied while developing a granulocytopenia and thrombocytopenia. The findings show that penicillamine had no chromosome-damaging effect as estimated by the micronucleus test and by the number of structural chromosomal aberrations.
ISSN:0165-1218
0027-5107
DOI:10.1016/0165-1218(79)90032-6