Trace elemental analysis of cancer-afflicted intestine by PIXE technique

Trace elemental analysis was carried out in the biological samples of cancer-afflicted intestine using the particle-induced X-ray emission technique (PIXE). A 2-MeV proton beam was employed to excite the samples. From the present results, it can be seen that the concentration of the elements Cr, Fe,...

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Published inBiological trace element research Vol. 102; no. 1-3; pp. 265 - 282
Main Authors Reddy, S Bhuloka, Charles, M John, Raju, G J Naga, Reddy, B Seetharami, Reddy, T Seshi, Lakshmi, P V B Rama, Vijayan, V
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.12.2004
Subjects
Biological samples
Cancer
Carcinogenic agents
Chromium - analysis
Humans
Intestinal Neoplasms - chemistry
Intestines - chemistry
Iron - analysis
Nickel - analysis
Reference Values
Small intestine
Spectrometry, X-Ray Emission
Tissues
Trace elements
Trace Elements - analysis
Zinc - analysis
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Summary:Trace elemental analysis was carried out in the biological samples of cancer-afflicted intestine using the particle-induced X-ray emission technique (PIXE). A 2-MeV proton beam was employed to excite the samples. From the present results, it can be seen that the concentration of the elements Cr, Fe, and Ni are higher in the cancerous tissue of the intestine than those observed in the normal tissue, whereas the concentration levels of the element Zn is slightly lower in the cancer tissue of intestine than that observed in the normal tissue. The concentrations of S, Cl, K, Ca, Ti, Mn, Co, and Cu in the cancer tissue of the intestine are in agreement with those observed in the normal tissues within standard deviations. The present results support the previous observations that Ni and Cr are carcinogenic agents. The observed slightly low levels of zinc in the cancer tissue of the intestine suggest that zinc could possibly inhibit the tumor growth and development of neoplastic transformation. For correctly assessing the role played by the trace elements in initiating, promoting, or inhibiting cancer in various organs, there is a need for the acquisition of more data by trace elemental analysis from several investigations of this type undertaken in different regions.
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ISSN:0163-4984
0163-4984
1559-0720
DOI:10.1385/BTER:102:1-3:265