Highly cross-linked arabinoxylans microspheres as a microbiota-activated carrier for colon-specific insulin delivery

[Display omitted] In vivo evaluation of arabinoxylans (AX) microspheres showed to protect insulin from degradation in the upper gastrointestinal tract and carrier insulin to colon. Insulin-loaded AX microspheres (50 UI/kg) decreased blood glucose level by 39% in diabetic rats with a maximum effect a...

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Published inEuropean journal of pharmaceutics and biopharmaceutics Vol. 163; pp. 16 - 22
Main Authors Morales-Burgos, A.M., Carvajal-Millan, E., Sotelo-Cruz, N., Rascón-Chu, A., Lizardi-Mendoza, J., López-Franco, Y.L., Martínez-Porchas, Marcel, Canett-Romero, R.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2021
Subjects
Arabinoxylans
Colon-targeted
Drug-delivery
Insulin carrier
Microspheres
Microspheres
Drug-delivery
Colon-targeted
Arabinoxylans
Insulin carrier
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Summary:[Display omitted] In vivo evaluation of arabinoxylans (AX) microspheres showed to protect insulin from degradation in the upper gastrointestinal tract and carrier insulin to colon. Insulin-loaded AX microspheres (50 UI/kg) decreased blood glucose level by 39% in diabetic rats with a maximum effect at 18 h post-administration, indicating that insulin remains bioactive. The continuous administration (4 days) of insulin-loaded AX microspheres improved the polyuria and increased the production of short-chain fatty acids, as well as Bifidobacterium and Bacteroides in diabetic rats compared to untreated diabetic rats. AX microspheres are a potential microbiota-activated carrier for colon-specific drug delivery and could be useful as a complementary treatment for diabetes.
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ISSN:0939-6411
1873-3441
DOI:10.1016/j.ejpb.2021.02.014