Synthesis of CDP-diglyceride from phosphatidylinositol and CMP

A reaction in which CDP-diglyceride and inositol are formed from 1-stearoyl, 2-arachidonoyl phosphatidylinositol and CMP occurs readily in dialyzed microsomal preparations from the mouse pancreas. The reaction is Mn 2+-dependent, and it is inhibited by each of the two products, CDP-diglyceride and m...

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Published inBiochemical and biophysical research communications Vol. 78; no. 1; pp. 364 - 371
Main Authors Hokin-Neaverson, Mabel, Sadeghian, Kenneth, Harris, Douglas W., Merrin, James S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 09.09.1977
Subjects
Animals
Cytidine Diphosphate Diglycerides - biosynthesis
Cytidine Monophosphate - metabolism
Cytosine Nucleotides - metabolism
Magnesium - pharmacology
Manganese - pharmacology
Mice
Microsomes - metabolism
Nucleoside Diphosphate Sugars - biosynthesis
Pancreas - metabolism
Phosphatidylinositols - metabolism
Phosphotransferases - metabolism
Ribonucleotides - pharmacology
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Summary:A reaction in which CDP-diglyceride and inositol are formed from 1-stearoyl, 2-arachidonoyl phosphatidylinositol and CMP occurs readily in dialyzed microsomal preparations from the mouse pancreas. The reaction is Mn 2+-dependent, and it is inhibited by each of the two products, CDP-diglyceride and myoinositol. It is presumed to involve the back-reaction of CDP-diglyceride: inositol phosphatidyltransferase (phosphatidyl-inositol synthetase, EC.2.7.8.11.)
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(77)91263-3