Evaluation of the protective effect of Myrtus communis in scopolamine-induced Alzheimer model through cholinergic receptors

• Published in: Gene Vol. 689; pp. 194 - 201
• Main Authors: Aykac, Asli, Ozbeyli, Dilek, Uncu, Murat, Ertaş, Büşra, Kılınc, Olca, Şen, Ali, Orun, Oya, Sener, Goksel
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 20.03.2019
• Subjects: AChE; BDNF; Muscarinic reseptor M1; Myrtus communis; Scopolamine; NBT; AChE; AD; Scopolamine; M1; TBS; DTT; BDNF; ACh; qRT-PCR; MDA; EDTA; MPO; mAChRs; BSA; TBS-T; GAL; PMSF; MC; BCIP; SCOP; Myrtus communis; Muscarinic reseptor M1; GSH; Muscarinic reseptor M
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2018.12.007

Alzheimer's disease is a progressive neurodegenerative disorder causing common health problem with increasing age. Evidences show that the key symptoms of AD are mainly caused by cholinergic system dysfunction which has a role in cognitive disorders. Cholinergic pathways especially muscarinic receptors like M1 subtype also have a major role in learning, memory, cognitive functions and emotional state. There is no available permanent treatment currently to cure AD or to change its progression. This study was designed to investigate the factors that play important role in pathogenesis of AD and to compare the effects of Galantamine treatment with effects of Myrtus communis treatment. The expression level of M1, ACh, BDNF; AChE activity, GSH level, MDA and MPO activity and AChE gene expression were investigated in scopolamine-induced rat model. Results showed that, administration of MC significantly improves the SCOP-induced reduction of latency and object recognition time; increasing BDNF, M1 and ACh receptor expression levels in the different brain regions. Additionally, MC showed an increased in AChE by enhancing GSH activity and reducing MDA level and MPO activity. In conclusion MC considered as a possible novel therapeutic approach that can be a valuable alternative way in the prevention and treatment of AD. •Myrtus communis treatment ameliorated short and long term memory in SCOP model.•Myrtus communis possibly be helpful for preventing oxidative stress in brain tissue.•Myrtus communis treatment may be used as effective as the Galantamine.•Myrtus communis treatment reduced acetylcholinesterase activity in brain.•Myrtus communis treatment was ideal in recovering the reduced M1 and BDNF levels.