Heat sensitivity of rat skin

Experiments were conducted to determine the heat sensitivity of normal tissues. The rat skin was selected as a suitable model. After inflation of the rat subcutis with air, anaesthetized animals were placed in a heated water bath with the upper part of this air pouch exposed to the hot water. A tota...

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Bibliographic Details
Published inEuropean journal of cancer Vol. 14; no. 11; pp. 1161 - 1166
Main Authors Okumura, Y., Reinhold, H.S.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.11.1978
Subjects
Animals
Dose-Response Relationship, Radiation
Hot Temperature - adverse effects
Male
Mathematics
Necrosis
Rats
Skin - pathology
Skin - radiation effects
Skin Physiological Phenomena
Skin Temperature
Time Factors
Water
X-Rays
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Summary:Experiments were conducted to determine the heat sensitivity of normal tissues. The rat skin was selected as a suitable model. After inflation of the rat subcutis with air, anaesthetized animals were placed in a heated water bath with the upper part of this air pouch exposed to the hot water. A total of 502 animals were treated with temperatures ranging from 42 to 47°C and exposure times of from 12 to 240 min. The intensity of damage was divided into 6 grades ranging from “no effect” to “maximum effect”. The relationship between the exposure time to heat and the required temperature for isoeffect damage was determined and expressed as t = a × b t , with a value of 0.51 for b( t = exposure time; T = temperatures; a = constant). The synergistic effect of heat combined with X-irradiation was also studied. When animals were X-irradiated within 6 hr after heat treatment, the synergistic effect was evident, but disappeared after 24 hr.
ISSN:0014-2964
DOI:10.1016/0014-2964(78)90221-9