Nutrition and Microbiome Interactions in Human Cancer

Individual physiologic responses to changes in dietary patterns can vary widely to affect cancer risk, which is driven by multiple host-specific factors (eg, genetics, epigenetics, inflammatory and metabolic states, and the colonizing microbiome). Emerging evidence indicates that diet-induced microb...

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Bibliographic Details
Published inJournal of the Academy of Nutrition and Dietetics Vol. 123; no. 3; pp. 504 - 514
Main Authors Daschner, Phillip J., Ross, Sharon, Seifried, Harold, Kumar, Amit, Flores, Roberto
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2023
Subjects
Cancer
Cancer etiology
Cancer prevention
Diet
Gastrointestinal Microbiome
Humans
Microbiome
Microbiota
Neoplasms
Nutrition
Nutritional Status
Cancer prevention
Cancer etiology
Nutrition
Cancer
Microbiome
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Summary:Individual physiologic responses to changes in dietary patterns can vary widely to affect cancer risk, which is driven by multiple host-specific factors (eg, genetics, epigenetics, inflammatory and metabolic states, and the colonizing microbiome). Emerging evidence indicates that diet-induced microbiota alterations are key modulators of several host functions important to tumor etiology, progression, and response to cancer therapy. Thus, diet may potentially be used to target alterations of the microbiota as an effective means to improve outcomes across the cancer continuum (from cancer prevention to tumor development and progression, to effects on treatment and survivorship). This review will focus on recent examples of functional interactions between dietary components (nutrients and non-nutrients) and the gastrointestinal microbiome, which are 2 critical and malleable environmental variables in cancer risk that affect host immune, metabolic, and cell signaling functions and may provide insights for novel cancer therapeutic and preventive strategies.
ISSN:2212-2672
2212-2680
DOI:10.1016/j.jand.2022.10.004