Laparoscopic Sentinel Node Mapping in Cervical and Endometrial Malignancies: A Case-Control Study Comparing Two Near-Infrared Fluorescence Systems

• Published in: Journal of minimally invasive gynecology Vol. 25; no. 1; p. 93
• Main Authors: Buda, Alessandro, Di Martino, Giampaolo, De Ponti, Elena, Passoni, Paolo, Sina, Federica, Reato, Claudio, Vecchione, Francesca, Giuliani, Daniela
• Format: Journal Article
• Language: English
• Published: United States 01.01.2018
• Subjects: Adult; Aged; Case-Control Studies; Endometrial Neoplasms - pathology; Female; Fluorescence; Humans; Indocyanine Green; Italy; Laparoscopy - methods; Lymph Nodes - diagnostic imaging; Lymph Nodes - pathology; Middle Aged; Neoplasm Staging; Operative Time; Sentinel Lymph Node - diagnostic imaging; Sentinel Lymph Node - pathology; Sentinel Lymph Node Biopsy - methods; Spectroscopy, Near-Infrared - methods; Uterine Cervical Neoplasms - pathology; Uterine Neoplasms - pathology; Italy; Sentinel node mapping; Endometrial cancer; Fluorescence near-infrared systems; Cervical cancer
• ISSN: 1553-4669
• DOI: 10.1016/j.jmig.2017.08.011

The goal of this study was to evaluate the intraoperative and perioperative surgical outcomes of 2 different florescence systems commonly used for sentinel lymph node (SLN) mapping in women with early-stage cervical cancer or endometrial cancer. Case-control study (Canadian Task Force classification II-2). The Gynecology Oncology Surgical Unit of the San Gerardo Hospital, Italy. Thirty-four consecutive women with early stage-cervical cancer (stage IA-1B1) or apparent confined stage I endometrial cancer were included in the study. Between October 2016 and May 2017, 34 patients underwent laparoscopic surgery with SLN mapping using indocyanine green dye: 22 women were mapped with the Storz 1S system (Karl Storz Endoscopy, Tuttlingen, Germany; Group A), whereas 12 women underwent planned surgery with the Novadaq PinPoint system (Novadaq, Mississauga, Ontario, Canada; Group B). We compared the surgical and perioperative outcomes of Group A and Group B. Patients in Group B had a shorter duration of the SLN mapping time than those in Group A (p = .0003). The median number of SLNs removed was 2 (range, 0-5) in Group A and 2 (range, 1-3) in Group B (p = .501). Bilateral mapping was 77.3% in Group A and 83.3% in Group B (p = .334), respectively. No differences were recorded in terms of body mass index, length of hospital stay, type of tumor, bilateral mapping, or number of lymph nodes removed. Body mass index was found to have no impact on the duration of the mapping (p = .353). From our preliminary experience we can conclude that both fluorescence systems are valid and applicable for SLN detection in the case of early-stage cervical or endometrial cancer. The PinPoint system seems to allow surgeons easier and faster identification of the SLNs, particularly in endometrial cancer patients.