LINC00174 is a favorable prognostic biomarker in glioblastoma via promoting proliferative phenotype

• Published in: Cancer biomarkers : section A of Disease markers Vol. 28; no. 4; pp. 421 - 427
• Main Authors: Wang, Zheng, Wang, Qiangwei, Bao, Zhaoshi, Guo, Liemei, Chen, Hongjin, Lv, Tao, Xu, Tianqi, Zhang, Xiaohua, Zhou, Caifang, Sun, Lihua
• Format: Journal Article
• Language: English
• Published: Netherlands IOS Press BV 01.01.2020
• Subjects: Adult; Animals; Biomarkers; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Brain - pathology; Brain - surgery; Brain cancer; Brain Neoplasms - genetics; Brain Neoplasms - mortality; Brain Neoplasms - pathology; Brain Neoplasms - surgery; Cell Line, Tumor; Cell proliferation; Cell Proliferation - genetics; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioblastoma; Glioblastoma - genetics; Glioblastoma - mortality; Glioblastoma - pathology; Glioblastoma - surgery; Glioma; Humans; Kaplan-Meier Estimate; Male; Mice; Middle Aged; Neoplasm Grading; Nucleotide sequence; Phenotypes; Prognosis; Ribonucleic acid; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Survival; Survival analysis; Tumors; Up-Regulation; Xenograft Model Antitumor Assays; LINC00174; proliferation; oncogene; prognosis; Gliblastoma
• ISSN: 1574-0153; 1875-8592
• DOI: 10.3233/CBM-191026

To investigate the expression pattern, prognostic value and biological functional of LINC00174 in glioma. In total, 140 glioma samples were collected as discovery cohort. TCGA RNA sequence dataset was obtained as validation set. Kaplan-Meier survival and multivariate Cox analysis were performed to evaluate survival difference. Furthermore, the biological function of LINC00174 was analyzed by clonogenic and intracranial tumor model assays. Overexpressed LINC00174 was significantly correlated with tumor grade as well as the higher mortality in survival analysis both in the discovery and the validation GBM cohorts. Besides, LINC00174 served as an independent prognostic indicator in glioblastoma patients. Additionally, knock down of LINC00174 expression significantly suppressed GBM cells' proliferation both in vitro and vivo. LINC00174 acts as an oncogene in glioma and may be a new potential therapeutic target.