Is COVID-19-Induced Platelet Activation a Cause of Concern for Patients with Cancer?

Patients with cancer are more susceptible to be infected by SARS-CoV-2 and develop severe outcomes including ICU admittance, mechanical ventilator support, and a high rate of mortality. Like mid-to late-stage cancer, SARS-CoV-2 infection is associated with platelet hyperactivity, systemic inflammati...

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Published inCancer research (Chicago, Ill.) Vol. 81; no. 5; pp. 1209 - 1211
Main Authors Lichtenberger, Lenard M, Vijayan, K Vinod
Format Journal Article
LanguageEnglish
Published United States 01.03.2021
Subjects
Blood Platelets - physiology
COVID-19 - diagnosis
COVID-19 - physiopathology
COVID-19 - virology
Humans
Inflammation - physiopathology
Neoplasms - diagnosis
Neoplasms - physiopathology
Platelet Activation - physiology
Risk Assessment - methods
Risk Assessment - statistics & numerical data
Risk Factors
SARS-CoV-2 - isolation & purification
SARS-CoV-2 - physiology
Thrombosis - physiopathology
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Abstract Patients with cancer are more susceptible to be infected by SARS-CoV-2 and develop severe outcomes including ICU admittance, mechanical ventilator support, and a high rate of mortality. Like mid-to late-stage cancer, SARS-CoV-2 infection is associated with platelet hyperactivity, systemic inflammation, thrombotic complications, and coagulopathy. Platelets also promote cancer cell growth, survival in circulation, and angiogenesis at sites of metastases. In this article, we will discuss the potential for platelets in the development of systemic inflammation and thrombosis in SARS-CoV-2-infected patients with cancer, with the concern that the platelet-induced pathogenic events are likely magnified in cancer patients with COVID-19.
AbstractList Abstract Patients with cancer are more susceptible to be infected by SARS-CoV-2 and develop severe outcomes including ICU admittance, mechanical ventilator support, and a high rate of mortality. Like mid-to late-stage cancer, SARS-CoV-2 infection is associated with platelet hyperactivity, systemic inflammation, thrombotic complications, and coagulopathy. Platelets also promote cancer cell growth, survival in circulation, and angiogenesis at sites of metastases. In this article, we will discuss the potential for platelets in the development of systemic inflammation and thrombosis in SARS-CoV-2–infected patients with cancer, with the concern that the platelet-induced pathogenic events are likely magnified in cancer patients with COVID-19.
Patients with cancer are more susceptible to be infected by SARS-CoV-2 and develop severe outcomes including ICU admittance, mechanical ventilator support, and a high rate of mortality. Like mid-to late-stage cancer, SARS-CoV-2 infection is associated with platelet hyperactivity, systemic inflammation, thrombotic complications, and coagulopathy. Platelets also promote cancer cell growth, survival in circulation, and angiogenesis at sites of metastases. In this article, we will discuss the potential for platelets in the development of systemic inflammation and thrombosis in SARS-CoV-2-infected patients with cancer, with the concern that the platelet-induced pathogenic events are likely magnified in cancer patients with COVID-19.
Author Vijayan, K Vinod
Lichtenberger, Lenard M
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  organization: Department of Integrative Biology & Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas. lenard.m.lichtenberger@uth.tmc.edu vvijayan@bcm.edu
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Snippet Patients with cancer are more susceptible to be infected by SARS-CoV-2 and develop severe outcomes including ICU admittance, mechanical ventilator support, and...
Abstract Patients with cancer are more susceptible to be infected by SARS-CoV-2 and develop severe outcomes including ICU admittance, mechanical ventilator...
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SubjectTerms Blood Platelets - physiology
COVID-19 - diagnosis
COVID-19 - physiopathology
COVID-19 - virology
Humans
Inflammation - physiopathology
Neoplasms - diagnosis
Neoplasms - physiopathology
Platelet Activation - physiology
Risk Assessment - methods
Risk Assessment - statistics & numerical data
Risk Factors
SARS-CoV-2 - isolation & purification
SARS-CoV-2 - physiology
Thrombosis - physiopathology
Title Is COVID-19-Induced Platelet Activation a Cause of Concern for Patients with Cancer?
URI https://www.ncbi.nlm.nih.gov/pubmed/33355186
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