Is COVID-19-Induced Platelet Activation a Cause of Concern for Patients with Cancer?

Patients with cancer are more susceptible to be infected by SARS-CoV-2 and develop severe outcomes including ICU admittance, mechanical ventilator support, and a high rate of mortality. Like mid-to late-stage cancer, SARS-CoV-2 infection is associated with platelet hyperactivity, systemic inflammati...

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Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 81; no. 5; pp. 1209 - 1211
Main Authors Lichtenberger, Lenard M, Vijayan, K Vinod
Format Journal Article
LanguageEnglish
Published United States 01.03.2021
Subjects
Blood Platelets - physiology
COVID-19 - diagnosis
COVID-19 - physiopathology
COVID-19 - virology
Humans
Inflammation - physiopathology
Neoplasms - diagnosis
Neoplasms - physiopathology
Platelet Activation - physiology
Risk Assessment - methods
Risk Assessment - statistics & numerical data
Risk Factors
SARS-CoV-2 - isolation & purification
SARS-CoV-2 - physiology
Thrombosis - physiopathology
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Summary:Patients with cancer are more susceptible to be infected by SARS-CoV-2 and develop severe outcomes including ICU admittance, mechanical ventilator support, and a high rate of mortality. Like mid-to late-stage cancer, SARS-CoV-2 infection is associated with platelet hyperactivity, systemic inflammation, thrombotic complications, and coagulopathy. Platelets also promote cancer cell growth, survival in circulation, and angiogenesis at sites of metastases. In this article, we will discuss the potential for platelets in the development of systemic inflammation and thrombosis in SARS-CoV-2-infected patients with cancer, with the concern that the platelet-induced pathogenic events are likely magnified in cancer patients with COVID-19.
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ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-20-3691