Surgical site complications of isolated salvage neck dissection post-radiotherapy and post-chemoradiotherapy – A cohort analysis (1997–2017)

• Published in: European journal of surgical oncology Vol. 49; no. 4; pp. 764 - 770
• Main Authors: Henneman, Roel, Rouwenhorst, Linda, Karakullukcu, M Baris, Smeele, Ludwig E., Lohuis, Peter FJM, van den Brekel, Michiel WM, Hamming-Vrieze, Olga, Jóźwiak, Katarzyna, Balm, Alfons JM
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2023
• Subjects: Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Chemoradiotherapy; Chemoradiotherapy - adverse effects; Classification; Cohort Studies; Complication; Head and Neck Neoplasms - radiotherapy; Head and Neck Neoplasms - surgery; Humans; Neck dissection; Neck Dissection - adverse effects; Surgical site infection; Wound; Surgical site infection; Complication; Wound; Chemoradiotherapy; Neck dissection; Classification
• ISSN: 0748-7983; 1532-2157
• DOI: 10.1016/j.ejso.2022.12.010

This study aims to quantify surgical site complications (SSC) after isolated salvage neck dissection (ND) compared with primary ND. Between 1997 and 2017 in the Netherlands Cancer Institute - Antoni van Leeuwenhoek, a total of 323 isolated NDs were performed in 308 patients: primary ND (n = 144), post-radiotherapy (RT) ND (n = 53) and post-chemoradiotherapy (CRT) ND (n = 126). Patient, tumor and therapy characteristics were recorded. SSCs were scored according to the Clavien-Dindo Classification (CDC). 101 NDs (31%) were complicated by at least one SSC. In total, 189 different SSCs occurred. Translated to CDC, 45 complications were grade 2, 25 grade 3a and 31 grade 3b. No significant difference in occurrence of SSC (CDC >1) was found between all groups. However, post-CRT, selective (SND) and modified radical ND and radical ND (MRND/RND) (p = 0.005), resection of sternocleidomastoid muscle (SCM) (p = 0.039) and duration of super selective ND surgery (p = 0.048) were significantly associated with more SSC. SCM muscle removal was associated with more surgical site infection (p = 0.045) and necrosis (p = 0.036). From week 10 post-RT/CRT, no difference in complication frequency with primary ND was seen. Post-CRT SND, MRND/RND and SCM muscle resection were associated with an increased incidence of SSCs. If oncologically possible, limit the extent of ND and when an MRND is inevitable, preserve the SCM muscle for optimal prevention of SSC. Concerning SSC, optimal timing of salvage ND is minimal 10 weeks after RT/CRT.