Role of the pituitary and the adrenals in mediating the effects of alcohol on testicular steroidogenesis in mice

We have previously demonstrated that intragastric administration of alcohol (1.24 g/kg body wt) to adult male mice results in suppression of testosterone production. We now report that the decline in peripheral testosterone levels in alcohol-treated mice is not accompanied by changes in plasma level...

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Bibliographic Details
Published inSteroids Vol. 34; no. 4; pp. 477 - 482
Main Authors Badr, Fouad M., Smith, M.Susan, Dalterio, Susan L., Bartke, Andrzej
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.1979
Subjects
Adrenal Glands - physiology
Adrenalectomy
Animals
Corticosterone - pharmacology
Estradiol - blood
Ethanol - pharmacology
Follicle Stimulating Hormone - blood
Luteinizing Hormone - blood
Male
Mice
Pituitary Gland - physiology
Testis - metabolism
Testosterone - blood
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Summary:We have previously demonstrated that intragastric administration of alcohol (1.24 g/kg body wt) to adult male mice results in suppression of testosterone production. We now report that the decline in peripheral testosterone levels in alcohol-treated mice is not accompanied by changes in plasma levels of luteinizing hormone, follicle stimulating hormone or estradiol-17β, and that it is markedly attenuated in adrenalectomized or adrenalectomized-corticosterone treated males.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0039-128X
1878-5867
DOI:10.1016/0039-128X(79)90108-9