Down-regulation of Coxsakie and Adenovirus Receptor during Embryo Implantation

In this study,real-time PCR and immunohistochemistry were used to detect coxsakie and adenovirus receptor (CAR) expression.Both localization and quantity were evaluated in the uteri ob-tained at days post coitus (dpc) 2.5,4.5,6.5,8.5.Outcome of PCR was assessed by 2-ΔΔCt method.Im-age Pro-Plus 6.0 s...

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Published in	Journal of Huazhong University of Science and Technology. Medical sciences Vol. 32; no. 1; pp. 103 - 106
Main Author	李豫峰赵焕王蓓蓓崔丹丹袁素珍贺晓郭娜陈宁宁
Format	Journal Article
Language	English
Published	Heidelberg Huazhong University of Science and Technology 01.02.2012
Subjects	Adenovirus and Animals Cavities Computer programs coxsackie Coxsackie and Adenovirus Receptor-Like Membrane Protein - metabolism Down-Regulation - physiology Embryo Implantation - physiology Embryos Epithelium Female Gene expression Immunohistochemistry implantation;endometrium Medicine Medicine & Public Health Mice mRNA Polymerase chain reaction receptor;embryo Sexual intercourse software Tight junctions Tissue Distribution Uterus - metabolism endometrium coxsackie and adenovirus receptor embryo implantation
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ISSN	1672-0733 1993-1352
DOI	10.1007/s11596-012-0018-6

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Abstract	In this study,real-time PCR and immunohistochemistry were used to detect coxsakie and adenovirus receptor (CAR) expression.Both localization and quantity were evaluated in the uteri ob-tained at days post coitus (dpc) 2.5,4.5,6.5,8.5.Outcome of PCR was assessed by 2-ΔΔCt method.Im-age Pro-Plus 6.0 software was used for quantifying mean density of CAR expression in immunohisto-chemical sections.We found relatively weak CAR expression in the mouse uteri during implantation window.PCR and immunohistochemistry revealed highest CAR expression was detected on dpc 2.5 followed by down-regulation of CAR at dpc 4.5 and 6.5 (with significant difference).At dpc 8.5,CAR expression was increased slightly again.It is concluded that during implantation,the expression of CAR mRNA and protein is declined,resulting in the impairment of tight junction between cavity epithelium cells.After implantation window closure,CAR appears again to maintain epithelium stability.CAR might play an important role during embryo implantation procedure.
AbstractList	In this study,real-time PCR and immunohistochemistry were used to detect coxsakie and adenovirus receptor (CAR) expression.Both localization and quantity were evaluated in the uteri ob-tained at days post coitus (dpc) 2.5,4.5,6.5,8.5.Outcome of PCR was assessed by 2-ΔΔCt method.Im-age Pro-Plus 6.0 software was used for quantifying mean density of CAR expression in immunohisto-chemical sections.We found relatively weak CAR expression in the mouse uteri during implantation window.PCR and immunohistochemistry revealed highest CAR expression was detected on dpc 2.5 followed by down-regulation of CAR at dpc 4.5 and 6.5 (with significant difference).At dpc 8.5,CAR expression was increased slightly again.It is concluded that during implantation,the expression of CAR mRNA and protein is declined,resulting in the impairment of tight junction between cavity epithelium cells.After implantation window closure,CAR appears again to maintain epithelium stability.CAR might play an important role during embryo implantation procedure. In this study, real-time PCR and immunohistochemistry were used to detect coxsakie and adenovirus receptor (CAR) expression. Both localization and quantity were evaluated in the uteri obtained at days post coitus (dpc) 2.5, 4.5, 6.5, 8.5. Outcome of PCR was assessed by 2 super(- Delta Delta Ct) method. Image Pro-Plus 6.0 software was used for quantifying mean density of CAR expression in immunohistochemical sections. We found relatively weak CAR expression in the mouse uteri during implantation window. PCR and immunohistochemistry revealed highest CAR expression was detected on dpc 2.5 followed by down-regulation of CAR at dpc 4.5 and 6.5 (with significant difference). At dpc 8.5, CAR expression was increased slightly again. It is concluded that during implantation, the expression of CAR mRNA and protein is declined, resulting in the impairment of tight junction between cavity epithelium cells. After implantation window closure, CAR appears again to maintain epithelium stability. CAR might play an important role during embryo implantation procedure. Summary In this study, real-time PCR and immunohistochemistry were used to detect coxsakie and adenovirus receptor (CAR) expression. Both localization and quantity were evaluated in the uteri obtained at days post coitus (dpc) 2.5, 4.5, 6.5, 8.5. Outcome of PCR was assessed by 2 −ΔΔCt method. Image Pro-Plus 6.0 software was used for quantifying mean density of CAR expression in immunohistochemical sections. We found relatively weak CAR expression in the mouse uteri during implantation window. PCR and immunohistochemistry revealed highest CAR expression was detected on dpc 2.5 followed by down-regulation of CAR at dpc 4.5 and 6.5 (with significant difference). At dpc 8.5, CAR expression was increased slightly again. It is concluded that during implantation, the expression of CAR mRNA and protein is declined, resulting in the impairment of tight junction between cavity epithelium cells. After implantation window closure, CAR appears again to maintain epithelium stability. CAR might play an important role during embryo implantation procedure. In this study, real-time PCR and immunohistochemistry were used to detect coxsakie and adenovirus receptor (CAR) expression. Both localization and quantity were evaluated in the uteri obtained at days post coitus (dpc) 2.5, 4.5, 6.5, 8.5. Outcome of PCR was assessed by 2(-ΔΔCt) method. Image Pro-Plus 6.0 software was used for quantifying mean density of CAR expression in immunohistochemical sections. We found relatively weak CAR expression in the mouse uteri during implantation window. PCR and immunohistochemistry revealed highest CAR expression was detected on dpc 2.5 followed by down-regulation of CAR at dpc 4.5 and 6.5 (with significant difference). At dpc 8.5, CAR expression was increased slightly again. It is concluded that during implantation, the expression of CAR mRNA and protein is declined, resulting in the impairment of tight junction between cavity epithelium cells. After implantation window closure, CAR appears again to maintain epithelium stability. CAR might play an important role during embryo implantation procedure. In this study, real-time PCR and immunohistochemistry were used to detect coxsakie and adenovirus receptor (CAR) expression. Both localization and quantity were evaluated in the uteri obtained at days post coitus (dpc) 2.5, 4.5, 6.5, 8.5. Outcome of PCR was assessed by 2(-ΔΔCt) method. Image Pro-Plus 6.0 software was used for quantifying mean density of CAR expression in immunohistochemical sections. We found relatively weak CAR expression in the mouse uteri during implantation window. PCR and immunohistochemistry revealed highest CAR expression was detected on dpc 2.5 followed by down-regulation of CAR at dpc 4.5 and 6.5 (with significant difference). At dpc 8.5, CAR expression was increased slightly again. It is concluded that during implantation, the expression of CAR mRNA and protein is declined, resulting in the impairment of tight junction between cavity epithelium cells. After implantation window closure, CAR appears again to maintain epithelium stability. CAR might play an important role during embryo implantation procedure.In this study, real-time PCR and immunohistochemistry were used to detect coxsakie and adenovirus receptor (CAR) expression. Both localization and quantity were evaluated in the uteri obtained at days post coitus (dpc) 2.5, 4.5, 6.5, 8.5. Outcome of PCR was assessed by 2(-ΔΔCt) method. Image Pro-Plus 6.0 software was used for quantifying mean density of CAR expression in immunohistochemical sections. We found relatively weak CAR expression in the mouse uteri during implantation window. PCR and immunohistochemistry revealed highest CAR expression was detected on dpc 2.5 followed by down-regulation of CAR at dpc 4.5 and 6.5 (with significant difference). At dpc 8.5, CAR expression was increased slightly again. It is concluded that during implantation, the expression of CAR mRNA and protein is declined, resulting in the impairment of tight junction between cavity epithelium cells. After implantation window closure, CAR appears again to maintain epithelium stability. CAR might play an important role during embryo implantation procedure.
Author	李豫峰赵焕王蓓蓓崔丹丹袁素珍贺晓郭娜陈宁宁
AuthorAffiliation	Reproductive
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References	Korn, Macal, Christian (CR16) 2006; 13 Bergelson, Krithivas, Celi (CR4) 1998; 72 Bergelson, Cunningham, Droguett (CR3) 1997; 275 Hotta, Honda, Naito (CR10) 2003; 143 Chen, Zhou, Yu (CR8) 2006; 98 Fok, Huang, Holland (CR17) 2007; 282 Fan, Chen, Ma (CR9) 2009; 28 Asher, Cerny, Weiler (CR7) 2005; 42 Lessey, Castelbaum (CR21) 2002; 3 James, Cross, Fisher (CR1) 1994; 266 Farmer, Morton, Snippe (CR19) 2009; 315 Dorner, Wegmann, Butz (CR6) 2005; 118 Stecker, Koschel, Wiedenmann (CR18) 2009; 101 Livak, Schmittgen (CR12) 2001; 25 Merviel, Challier, Carbillon (CR2) 2001; 16 Zen, Liu, McCall (CR20) 2005; 16 Yamashita, Ino, Kawabata (CR14) 2007; 121 Sachs, Rauen, Ramamurthy (CR15) 2002; 60 Raschperger, Thyberg, Pettersson (CR5) 2006; 312 Anders, Vieth, Röcken (CR13) 2009; 100 Giaginis, Zarros, Papaefthymiou (CR11) 2008; 17 Walters, Freimuth, Moninger (CR22) 2002; 110 E. Raschperger (18_CR5) 2006; 312 M. Anders (18_CR13) 2009; 100 K.J. Livak (18_CR12) 2001; 25 C. James (18_CR1) 1994; 266 B.A. Lessey (18_CR21) 2002; 3 Y. Hotta (18_CR10) 2003; 143 P. Merviel (18_CR2) 2001; 16 D.R. Asher (18_CR7) 2005; 42 P.T. Fok (18_CR17) 2007; 282 K. Zen (18_CR20) 2005; 16 J.M. Bergelson (18_CR3) 1997; 275 J.W. Chen (18_CR8) 2006; 98 C. Farmer (18_CR19) 2009; 315 M.D. Sachs (18_CR15) 2002; 60 W.M. Korn (18_CR16) 2006; 13 K. Stecker (18_CR18) 2009; 101 L.S. Fan (18_CR9) 2009; 28 R.W. Walters (18_CR22) 2002; 110 C.T. Giaginis (18_CR11) 2008; 17 M. Yamashita (18_CR14) 2007; 121 A.A. Dorner (18_CR6) 2005; 118 J.M. Bergelson (18_CR4) 1998; 72 12297051 - Cell. 2002 Sep 20;110(6):789-99 12350512 - Urology. 2002 Sep;60(3):531-6 15864812 - Genesis. 2005 Jun;42(2):77-85 16628228 - Cancer Gene Ther. 2006 Aug;13(8):792-7 9420240 - J Virol. 1998 Jan;72(1):415-9 16543498 - Circ Res. 2006 Apr 14;98(7):923-30 17546646 - Int J Cancer. 2007 Oct 15;121(8):1690-6 9036860 - Science. 1997 Feb 28;275(5304):1320-3 16542650 - Exp Cell Res. 2006 May 15;312(9):1566-80 15800062 - Mol Biol Cell. 2005 Jun;16(6):2694-703 11694740 - Fetal Diagn Ther. 2001 Nov-Dec;16(6):364-71 19527712 - Exp Cell Res. 2009 Sep 10;315(15):2637-47 19142187 - Br J Cancer. 2009 Jan 27;100(2):352-9 19773761 - Br J Cancer. 2009 Nov 3;101(9):1574-9 12007287 - Rev Endocr Metab Disord. 2002 May;3(2):107-17 11846609 - Methods. 2001 Dec;25(4):402-8 12763576 - Brain Res Dev Brain Res. 2003 Jun 12;143(1):1-13 18558015 - World J Surg Oncol. 2008 Jun 17;6:59 17210569 - J Biol Chem. 2007 Mar 9;282(10):7512-21 16079292 - J Cell Sci. 2005 Aug 1;118(Pt 15):3509-21 19619453 - Ai Zheng. 2009 Mar;28(3):333-6 7985020 - Science. 1994 Dec 2;266(5190):1508-18
References_xml	– volume: 16 start-page: 364 issue: 6 year: 2001 end-page: 371 ident: CR2 article-title: The role of integrins in human embryo implantation publication-title: Fetal Diagn Ther doi: 10.1159/000053942 – volume: 3 start-page: 107 issue: 2 year: 2002 end-page: 117 ident: CR21 article-title: Integrins and implantation in the human publication-title: Rev Endocr Metab Disorders doi: 10.1023/A:1015450727580 – volume: 275 start-page: 1320 issue: 5304 year: 1997 end-page: 1323 ident: CR3 article-title: Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5 publication-title: Science doi: 10.1126/science.275.5304.1320 – volume: 312 start-page: 1566 issue: 9 year: 2006 end-page: 1580 ident: CR5 article-title: The coxsackie- and adenovirus receptor (CAR) is an marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2006.01.025 – volume: 118 start-page: 3509 issue: 15 year: 2005 end-page: 3521 ident: CR6 article-title: Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development publication-title: J Cell Sci doi: 10.1242/jcs.02476 – volume: 100 start-page: 352 issue: 2 year: 2009 end-page: 359 ident: CR13 article-title: Loss of the coxsackie and adenovirus receptor contributes to gastric cancer progression publication-title: Br J Cancer doi: 10.1038/sj.bjc.6604876 – volume: 282 start-page: 7512 issue: 10 year: 2007 end-page: 7521 ident: CR17 article-title: The Coxsackie and adenovirus receptor binds microtubules and plays a role in cell migration publication-title: J Biol Chem doi: 10.1074/jbc.M607230200 – volume: 101 start-page: 1574 issue: 9 year: 2009 end-page: 1579 ident: CR18 article-title: Loss of Coxsackie and adenovirus receptor downregulates alpha-catenin expression publication-title: Br J Cancer doi: 10.1038/sj.bjc.6605331 – volume: 28 start-page: 333 issue: 3 year: 2009 end-page: 336 ident: CR9 article-title: Research advance on role of Coxsackie and adenovirus receptor (CAR) in tumor progression publication-title: Aizheng (Chinese) – volume: 121 start-page: 1690 issue: 8 year: 2007 end-page: 1696 ident: CR14 article-title: Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells publication-title: Int J Cancer doi: 10.1002/ijc.22852 – volume: 17 start-page: 59 issue: 6 year: 2008 ident: CR11 article-title: Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: possible clinical implications publication-title: World J Surg Oncol doi: 10.1186/1477-7819-6-59 – volume: 25 start-page: 402 issue: 4 year: 2001 end-page: 408 ident: CR12 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 266 start-page: 1508 issue: 5190 year: 1994 end-page: 1518 ident: CR1 article-title: Implantation and the plancenta: Key pieces of the development puzzle publication-title: Science doi: 10.1126/science.7985020 – volume: 16 start-page: 2694 year: 2005 end-page: 2703 ident: CR20 article-title: Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils publication-title: Mol Bio Cell doi: 10.1091/mbc.E05-01-0036 – volume: 72 start-page: 415 issue: 1 year: 1998 end-page: 419 ident: CR4 article-title: The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses publication-title: J Virol – volume: 315 start-page: 2637 issue: 15 year: 2009 end-page: 2647 ident: CR19 article-title: Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2009.06.008 – volume: 98 start-page: 923 issue: 7 year: 2006 end-page: 930 ident: CR8 article-title: Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves publication-title: Circ Res doi: 10.1161/01.RES.0000218041.41932.e3 – volume: 42 start-page: 77 issue: 2 year: 2005 end-page: 85 ident: CR7 article-title: Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development publication-title: Genesis doi: 10.1002/gene.20127 – volume: 60 start-page: 531 issue: 3 year: 2002 end-page: 536 ident: CR15 article-title: Integrin alpha(v) and coxsackie adenovirus receptor expression in clinical bladder cancer publication-title: Urology doi: 10.1016/S0090-4295(02)01748-X – volume: 143 start-page: 1 issue: 1 year: 2003 end-page: 13 ident: CR10 article-title: Developmental distribution of coxsackie virus and adenovirus receptor localized in the nervous system publication-title: Brain Res Dev Brain Res doi: 10.1016/S0165-3806(03)00035-X – volume: 110 start-page: 789 issue: 6 year: 2002 end-page: 799 ident: CR22 article-title: Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape publication-title: Cell doi: 10.1016/S0092-8674(02)00912-1 – volume: 13 start-page: 792 issue: 8 year: 2006 end-page: 797 ident: CR16 article-title: Expression of the coxsackievirus- and adenovirus receptor in gastrointestinal cancer correlates with tumor differentiation publication-title: Cancer Gene Ther doi: 10.1038/sj.cgt.7700947 – volume: 28 start-page: 333 issue: 3 year: 2009 ident: 18_CR9 publication-title: Aizheng (Chinese) – volume: 16 start-page: 364 issue: 6 year: 2001 ident: 18_CR2 publication-title: Fetal Diagn Ther doi: 10.1159/000053942 – volume: 101 start-page: 1574 issue: 9 year: 2009 ident: 18_CR18 publication-title: Br J Cancer doi: 10.1038/sj.bjc.6605331 – volume: 16 start-page: 2694 year: 2005 ident: 18_CR20 publication-title: Mol Bio Cell doi: 10.1091/mbc.E05-01-0036 – volume: 121 start-page: 1690 issue: 8 year: 2007 ident: 18_CR14 publication-title: Int J Cancer doi: 10.1002/ijc.22852 – volume: 98 start-page: 923 issue: 7 year: 2006 ident: 18_CR8 publication-title: Circ Res doi: 10.1161/01.RES.0000218041.41932.e3 – volume: 25 start-page: 402 issue: 4 year: 2001 ident: 18_CR12 publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 266 start-page: 1508 issue: 5190 year: 1994 ident: 18_CR1 publication-title: Science doi: 10.1126/science.7985020 – volume: 3 start-page: 107 issue: 2 year: 2002 ident: 18_CR21 publication-title: Rev Endocr Metab Disorders doi: 10.1023/A:1015450727580 – volume: 282 start-page: 7512 issue: 10 year: 2007 ident: 18_CR17 publication-title: J Biol Chem doi: 10.1074/jbc.M607230200 – volume: 110 start-page: 789 issue: 6 year: 2002 ident: 18_CR22 publication-title: Cell doi: 10.1016/S0092-8674(02)00912-1 – volume: 60 start-page: 531 issue: 3 year: 2002 ident: 18_CR15 publication-title: Urology doi: 10.1016/S0090-4295(02)01748-X – volume: 315 start-page: 2637 issue: 15 year: 2009 ident: 18_CR19 publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2009.06.008 – volume: 275 start-page: 1320 issue: 5304 year: 1997 ident: 18_CR3 publication-title: Science doi: 10.1126/science.275.5304.1320 – volume: 100 start-page: 352 issue: 2 year: 2009 ident: 18_CR13 publication-title: Br J Cancer doi: 10.1038/sj.bjc.6604876 – volume: 42 start-page: 77 issue: 2 year: 2005 ident: 18_CR7 publication-title: Genesis doi: 10.1002/gene.20127 – volume: 312 start-page: 1566 issue: 9 year: 2006 ident: 18_CR5 publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2006.01.025 – volume: 118 start-page: 3509 issue: 15 year: 2005 ident: 18_CR6 publication-title: J Cell Sci doi: 10.1242/jcs.02476 – volume: 72 start-page: 415 issue: 1 year: 1998 ident: 18_CR4 publication-title: J Virol doi: 10.1128/JVI.72.1.415-419.1998 – volume: 13 start-page: 792 issue: 8 year: 2006 ident: 18_CR16 publication-title: Cancer Gene Ther doi: 10.1038/sj.cgt.7700947 – volume: 17 start-page: 59 issue: 6 year: 2008 ident: 18_CR11 publication-title: World J Surg Oncol doi: 10.1186/1477-7819-6-59 – volume: 143 start-page: 1 issue: 1 year: 2003 ident: 18_CR10 publication-title: Brain Res Dev Brain Res doi: 10.1016/S0165-3806(03)00035-X – reference: 16079292 - J Cell Sci. 2005 Aug 1;118(Pt 15):3509-21 – reference: 12350512 - Urology. 2002 Sep;60(3):531-6 – reference: 16628228 - Cancer Gene Ther. 2006 Aug;13(8):792-7 – reference: 12007287 - Rev Endocr Metab Disord. 2002 May;3(2):107-17 – reference: 9036860 - Science. 1997 Feb 28;275(5304):1320-3 – reference: 19527712 - Exp Cell Res. 2009 Sep 10;315(15):2637-47 – reference: 11694740 - Fetal Diagn Ther. 2001 Nov-Dec;16(6):364-71 – reference: 19773761 - Br J Cancer. 2009 Nov 3;101(9):1574-9 – reference: 7985020 - Science. 1994 Dec 2;266(5190):1508-18 – reference: 12297051 - Cell. 2002 Sep 20;110(6):789-99 – reference: 9420240 - J Virol. 1998 Jan;72(1):415-9 – reference: 19142187 - Br J Cancer. 2009 Jan 27;100(2):352-9 – reference: 12763576 - Brain Res Dev Brain Res. 2003 Jun 12;143(1):1-13 – reference: 17210569 - J Biol Chem. 2007 Mar 9;282(10):7512-21 – reference: 16543498 - Circ Res. 2006 Apr 14;98(7):923-30 – reference: 16542650 - Exp Cell Res. 2006 May 15;312(9):1566-80 – reference: 17546646 - Int J Cancer. 2007 Oct 15;121(8):1690-6 – reference: 19619453 - Ai Zheng. 2009 Mar;28(3):333-6 – reference: 11846609 - Methods. 2001 Dec;25(4):402-8 – reference: 15800062 - Mol Biol Cell. 2005 Jun;16(6):2694-703 – reference: 15864812 - Genesis. 2005 Jun;42(2):77-85 – reference: 18558015 - World J Surg Oncol. 2008 Jun 17;6:59
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Snippet	In this study,real-time PCR and immunohistochemistry were used to detect coxsakie and adenovirus receptor (CAR) expression.Both localization and quantity were... Summary In this study, real-time PCR and immunohistochemistry were used to detect coxsakie and adenovirus receptor (CAR) expression. Both localization and... In this study, real-time PCR and immunohistochemistry were used to detect coxsakie and adenovirus receptor (CAR) expression. Both localization and quantity...
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SubjectTerms	Adenovirus and Animals Cavities Computer programs coxsackie Coxsackie and Adenovirus Receptor-Like Membrane Protein - metabolism Down-Regulation - physiology Embryo Implantation - physiology Embryos Epithelium Female Gene expression Immunohistochemistry implantation;endometrium Medicine Medicine & Public Health Mice mRNA Polymerase chain reaction receptor;embryo Sexual intercourse software Tight junctions Tissue Distribution Uterus - metabolism
Title	Down-regulation of Coxsakie and Adenovirus Receptor during Embryo Implantation
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