Radioembolization-Induced Gastroduodenal Ulcer

• Published in: The American surgeon Vol. 78; no. 5; pp. 621 - 623
• Main Authors: GARG, Malika, STRAUCHEN, James A, WARNER, Richard R. P, DIVINO, Celia M
• Format: Journal Article
• Language: English
• Published: Atlanta, GA Southeastern Surgical Congress 01.05.2012; SAGE PUBLICATIONS, INC
• Subjects: Biological and medical sciences; Carcinoid Tumor - therapy; Diagnosis, Differential; Duodenal Ulcer - diagnosis; Duodenal Ulcer - etiology; Embolization, Therapeutic - adverse effects; Embolization, Therapeutic - methods; Endoscopy, Gastrointestinal; Follow-Up Studies; General aspects; Humans; Intestinal Neoplasms - therapy; Male; Medical imaging; Medical sciences; Medical treatment; Microspheres; Middle Aged; Peptic Ulcer - diagnosis; Peptic Ulcer - etiology; Radiation Injuries - diagnosis; Radiation Injuries - etiology; Radiation therapy; Radiopharmaceuticals - administration & dosage; Radiopharmaceuticals - adverse effects; Radiopharmaceuticals - therapeutic use; Stomach Ulcer - diagnosis; Stomach Ulcer - etiology; Tumors; Ulcers; Veins & arteries; Medicine; Ulcer; Gastroduodenal; Treatment; Surgery
• ISSN: 0003-1348; 1555-9823
• DOI: 10.1177/000313481207800550

The microspheres measuring between 25 and 55 mm in diameter are trapped in the vasculature of the tumor, releasing b-radiation with maximum energy of 2.27 MeV and mean range of 2.5 mm. The half-life of Yttrium-90 is 2.67 days, so that over 92 per cent of the radiation dose is delivered during the first 11 days after administration of the treatment.1, 2 In the treatment of primary and metastatic tumors of the liver, this technique involves administration of the microspheres into the hepatic artery through intrahepatic catheterization. Radiation ulcers can develop in the serosal surface unlike usual peptic ulcers, which develop in the mucosal layer.4 As a result of the unique pathophysiology, radiation-induced ulcers do not respond to conventional acid-suppressing medications like proton pump inhibitors.