Manifestation and associated factors of systemic and local allergy among patients with allergic fungal rhinosinusitis: An observational study

• Published in: Medicine (Baltimore) Vol. 103; no. 19; p. e38084
• Main Authors: Vo, An Binh, Thai, Truc Thanh, Pham, Duy Le, Pham, Huu Kien
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 10.05.2024
• Subjects: Adult; Aged; Allergic Fungal Sinusitis; Female; Humans; Immunoglobulin E - blood; Male; Middle Aged; Mycoses - complications; Mycoses - diagnosis; Mycoses - epidemiology; Mycoses - immunology; Nasal Provocation Tests; Observational Study; Prevalence; Rhinitis, Allergic - complications; Rhinitis, Allergic - diagnosis; Rhinitis, Allergic - epidemiology; Rhinitis, Allergic - immunology; Sinusitis - complications; Sinusitis - diagnosis; Sinusitis - epidemiology; Sinusitis - immunology; Sinusitis - microbiology; Skin Tests
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000038084

Allergic fungal rhinosinusitis (AFRS) is a subtype of chronic rhinosinusitis, characterized by excessive immune responses to environmental molds or fungi. The diagnosis and classification of AFRS into systemic and local types remain clinically challenging due to overlapping characteristics. This study investigated the prevalence of AFRS, its manifestation and associated factors in systemic and local AFRS. A total of 200 patients diagnosed with fungal rhinosinusitis underwent both skin provocation tests (SPT) and nasal provocation tests (NPT) to confirm AFRS and classify systemic and local types. Patients were considered to have AFRS if either the SPT or NPT was positive. Among these, patients with systemic AFRS were those who had a SPT positive. Local AFRS was when patients had a negative SPT and a positive NPT. Medical history, serum total IgE level, nasal endoscopy examinations, and CT scans were also recorded. Most patients were female (65.8%), with a mean age of 55.6 years (SD = 14.4). Based on the SPT and NPT results, 31% of patients (n = 62) were diagnosed with AFRS. Among these, 54.8% (n = 34) had systemic AFRS, while 45.2% (n = 28) had local AFRS. Patients with AFRS exhibited significantly higher levels of total IgE, eosinophils, and more pronounced signs and symptoms compared to those without AFRS. However, no statistically significant differences were observed between patients with systemic AFRS and those with local AFRS. AFRS was prevalent in our study. Among patients with AFRS, both systemic AFRS and local AFRS were also prevalent. While allergic indicators and clinical presentations can aid in AFRS diagnosis, minimal distinctions were observed between systemic and local AFRS. A comprehensive assessment incorporating both local and systemic allergic responses through provocation tests, such as a combination of skin and nasal tests, is imperative for optimizing AFRS diagnosis and management.