Effects of four novel genetic polymorphisms on clopidogrel efficacy in Chinese acute coronary syndromes patients

• Published in: Gene Vol. 623; pp. 63 - 71
• Main Authors: Xiao, Fei-Yan, Liu, Min, Chen, Bi-Lian, Cao, Shan, Fan, Lan, Liu, Zhao-Qian, Zhou, Hong-Hao, Zhang, Wei, Zhou, Gan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.08.2017
• Subjects: Acute Coronary Syndrome - diagnosis; Acute Coronary Syndrome - drug therapy; Acute Coronary Syndrome - genetics; Acute coronary syndromes; Aged; Case-Control Studies; Clinical outcomes; Clopidogrel; Female; Genetic Loci; Genetic polymorphisms; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors - therapeutic use; Polymorphism, Single Nucleotide; SNP; Ticlopidine - analogs & derivatives; Ticlopidine - therapeutic use; Treatment Outcome; NSTEMI; OR; CI; CAD; MACCE; UA; Genetic polymorphisms; Clinical outcomes; ACS; SD; SNP; PCI; STEMI; Clopidogrel; Acute coronary syndromes; AMI; DAPT
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2017.04.029

Dual antiplatelet therapy is the gold standard for the clinical treatment of coronary artery disease, especially for acute coronary syndromes patients. However, a substantial number of patients do not respond to clopidogrel despite a standardized dosage regimen, and this is directly associated with poor prognosis. Genetic polymorphisms may be one of the most important factors that contribute to this phenomenon. In this study, we aimed to detect new single nucleotide polymorphisms that can influence the efficacy of clopidogrel in 851 acute coronary syndromes (ACS) patients. Four outcomes (cerebrovascular event, Acute Myocardium Infarction, unstable angina and death) were used as endpoints among three cohorts (northern, central and southern China) of acute coronary syndromes patients. Three SNPs (rs2244923, rs2773341 and rs34428341) were significantly associated with at least one outcome in all subjects. One SNP rs16863352, may play a role in predicting unstable angina in acute coronary syndrome patients ≥75years of age. •This is a multi-center big size research.•The four SNPs in the paper were studied in the first time.•Stratification analysis was used and adjusted for covariant.