The effect of remote ischemic pre-conditioning on pulmonary vascular pressure and gas exchange in healthy humans during hypoxia

• Published in: Respiratory physiology & neurobiology Vol. 261; pp. 62 - 66
• Main Authors: Kim, Chul-Ho, Sajgalik, Pavol, Van Iterson, Erik H., Jae, Sae Young, Johnson, Bruce D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2019
• Subjects: Breathing efficiency; Low oxygen; Pulmonary pressure; rIPC; Breathing efficiency; Pulmonary pressure; Low oxygen; rIPC
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2019.01.008

•Hypoxic exercise increases pulmonary arterial pressure.•The rIPC attenuates hypoxic exercise induced elevation in pulmonary arterial pressure.•The rIPC improves pulmonary gas exchange during hypoxic exercise. This study investigated whether rIPC alters the typical changes in pulmonary arterial pressure, pulmonary gas exchange associated with exercise in hypoxia. 16 healthy adults were randomized to either rIPC treatment (n = 8) or control (n = 8). Afterward, subjects performed supine ergometry at constant load (30 W, 40˜50 rpm) for 25 min during hypoxia (12.5% O2). Following a 90˜120 min rest, either rIPC or sham treatment was performed, which was then followed by post-assessment exercise. Throughout exercise, pulmonary arterial systolic pressure (PASP) and mean pulmonary arterial pressure (mPAP) were measured via echocardiography, while pulmonary gas exchange was being assessed. The rICP group demonstrated improved PASP and mPAP (p < 0.05), whereas the control group did not. Additionally, breathing efficiency (VE/VCO2) and end-tidal CO2 (PETCO2) were improved in rIPC group (p < 0.05), but not in controls. These data suggest that rIPC contributes to reduced pulmonary arterial pressure, and improved pulmonary gas exchange during hypoxic exercise. However, follow-up studies are needed to apply these findings to patient care settings.