Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp

• Published in: Bioorganic & medicinal chemistry letters Vol. 27; no. 14; pp. 3123 - 3126
• Main Authors: Le, Tu Cam, Yim, Chae-Yoon, Park, Songhee, Katila, Nikita, Yang, Inho, Song, Myoung Chong, Yoon, Yeo Joon, Choi, Dong-Young, Choi, Hyukjae, Nam, Sang-Jip, Fenical, William
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.07.2017; Elsevier
• Subjects: Actinobacteria - metabolism; Alkaloids - chemistry; Alkaloids - isolation & purification; Alkaloids - pharmacology; Amyloid beta-Peptides - metabolism; Amyloid Precursor Protein Secretases - antagonists & inhibitors; Amyloid Precursor Protein Secretases - metabolism; BACE1 inhibitor; Cell Line, Tumor; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Enzyme Activation - drug effects; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - isolation & purification; Enzyme Inhibitors - pharmacology; Geologic Sediments - microbiology; Humans; Life Sciences & Biomedicine; Lodopyridone; Magnetic Resonance Spectroscopy; Marine natural products; Molecular Conformation; Neurons - cytology; Neurons - drug effects; Neurons - metabolism; Peptide Fragments - metabolism; Pharmacology & Pharmacy; Physical Sciences; Pyridones - chemistry; Pyridones - isolation & purification; Pyridones - pharmacology; Saccharomonospora; Science & Technology; BACE1 inhibitor; Saccharomonospora; Marine natural products; Lodopyridone; METABOLITES; ALZHEIMERS-DISEASE; NATURAL-PRODUCTS; FUTURE PERSPECTIVES; RESOURCE
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/j.bmcl.2017.05.035

[Display omitted] HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A–C show weak inhibitory activities on the β-site amyloid precursor protein cleaving enzyme 1 (BACE1).