Pine pollen inhibits cell apoptosis-related protein expression in the cerebral cortex of mice with arsenic poisoning

• Published in: Neural regeneration research Vol. 7; no. 12; pp. 896 - 899
• Main Authors: Luo, Yanhong, Wei, Yaodong, Wang, Taizhong, Chen, Dongzhu, Lu, Tiansheng, Wu, Ruibo, Si, Keke
• Format: Journal Article
• Language: English
• Published: India Medknow Publications & Media Pvt. Ltd 25.04.2012; Department of Clinical Biochemistry and Molecular Biology, Youjiang Medical College for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China%Department of Biochemistry and Molecular Biology, Youjiang Medical College for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China%Grade 2008, Department of Medical Laboratory Science, Youjiang Medical College for Nationalities, Baise 533000, Guangxi Zhuang Autonomous Region, China; Medknow Publications & Media Pvt Ltd
• Subjects: Apoptosis; Arsenic; Arsenic content; Bax蛋白; Brain; Flow cytometry; Immunoglobulins; Kinases; Laboratory animals; Poisoning; Protein expression; Proteins; Research and Report: Traditional Chinese Medicine and Neuroregeneration; 大脑皮层; 小鼠; 松花粉; 相关蛋白表达; 砷中毒; 细胞凋亡; 酶联免疫吸附法; Beijing China; United States > US; China; cerebral cortex; apoptosis; pine pollen; neural regeneration; arsenic poisoning
• ISSN: 1673-5374; 1876-7958
• DOI: 10.3969/j.issn.1673-5374.2012.12.003

Previous studies have demonstrated that pine pollen can inhibit cerebral cortical cell apoptosis in mice with arsenic poisoning. The present study sought to detect the influence of pine pollen on apoptosis-related proteins. Immunohistochemistry, western blotting and enzyme-linked immunosorbent assays were used to measure the levels of apoptosis-related proteins in the cerebral cortex of mice with arsenic poisoning. Results indicated that pine pollen suppressed cell apoptosis in the cerebral cortex of arsenic-poisoned mice by reducing Bax, Bcl-2 protein expression and increasing p53 protein expression.